Comportamento da osteomielite em pacientes pediátricos
DOI:
https://doi.org/10.5281/zenodo.10620909Palavras-chave:
osteomielite, microbiologia, tratamento farmacológico, terapia, cirurgiaResumo
Introdução: a osteomielite é uma infeção óssea, que afecta frequentemente afecta frequentemente doentes do grupo etário pediátrico, com um comportamento variado, dependendo da via de entrada no osso, do tipo de germe e da resposta do hospedeiro.
Objectivo: mostrar o comportamento de um grupo de doentes pediátricos com osteomielite.
Método: foi realizado um estudo observacional descritivo em 39 pacientes tratados no Hospital Pediátrico Provincial Dr. Eduardo Agramonte Piña, na cidade de Camagüey, no período de 1 de janeiro de 2018 a 31 de dezembro de 2022, e um total de 60 meses com diagnóstico de osteomielite.
Resultados: dos 39 pacientes investigados, o sexo masculino predominou sobre o feminino (2,2 para 1). A idade média foi de 9 anos. A média de permanência hospitalar foi de 14,8 dias. As regiões mais acometidas foram as mãos, o fêmur e a tíbia distal. O tratamento cirúrgico predominou (2,2 para 1) sobre o tratamento conservador. A via hematogénica para o osso foi a mais frequente em 86,4% dos casos. A transição para a cronicidade é a complicação mais frequentemente encontrada (33%). O germe mais frequentemente isolado foi o Staphylococcus aureus (em 85% dos doentes). Os antimicrobianos mais frequentemente indicados foram a cefazolina, a amicacina e a fosfocina.
Conclusões: os resultados obtidos na pesquisa fornecem elementos importantes do ponto de vista epidemiológico em pacientes pediátricos portadores de osteomielite, permitindo a implementação de estratégias diagnósticas e terapêuticas neste grupo de pacientes.
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Congedi S, Minotti C, Giaquinto C, Da Dalt L, Donà D. Acute infectious osteomyelitis in children: new treatment strategies for an old enemy. World J Ped [Internet]. 2020 oct. [Citado 26 Jun 2023]; 16(5):446-455. DOI: https://doi.org/10.1007/s12519-020-00359-z
Dolitsky R, DePaola K, Fernicola J, Collins C. Pediatric musculoskeletal infections. Ped Clin North Am [Internet]. 2020 feb. [Citado 26 Jun 2023]; 67(1):59-69. DOI: https://doi.org/10.1016/j.pcl.2019.09.001
Hwang J, Kelham SA. Osteomyelitis. JAAPA [Internet]. 2022 sep. [Citado 26 Jun 2023]; 35(9):57-58. DOI: https://doi.org/10.1097/01.JAA.0000854520.27186.dd
Legister CS, Blumberg TJ, Copley LA, Schoencker JG, Sandres JS, Miller DJ. Pediatric musculoskeletal infection roundtable: tips and tricks for streamlining care in common scenarios. JPOSNA [Internet]. 2022 nov. [Citado 26 Jun 2023]; 4(4):1-16. DOI: https://doi.org/10.55275/JPOSNA-2022-570
Stephan AM, Faino A, Caglar D, Klein EJ. Clinical presentation of acute osteomyelitis in the pediatric emergency department. Ped Emerg Care [Internet]. 2022 jan. [Citado 26 Jun 2023]; 38(1):e209-e213. DOI: https://doi.org/10.1097/PEC.0000000000002217
Woods CR, Bradley JS, Chatterjee A, Copley LA, Robinson J, Kronman MP, et al. Clinical practice guideline by the pediatric infectious diseases society and the infectious diseases society of America: 2021 guideline on diagnosis and management of acute hematogenous osteomyelitis in pediatrics. J Ped Inf Dis Soc [Internet]. 2021 sep. [Citado 26 Jun 2023]; 10(8):801-844. DOI: https://doi.org/10.1093/jpids/piab027
Walter N, Baertl S, Alt V, Rupp M. What is the burden of osteomyelitis in Germany? An analysis of inpatient data from 2008 through 2018. BMC Infect Dis [Internet]. 2021 jun. [Citado 26 Jun 2023]; 21(1):550. DOI: https://doi.org/10.1186/s12879-021-06274-6
Gigante A, Coppa V, Marinelli M, Giampaolini N, Falcioni D, Specchia N. Acute osteomyelitis and septic arthritis in children: a systematic review of systematic reviews. Eur Rev Med Pharmacol Sci [Internet]. 2019 apr. [Citado 26 Jun 2023]; 23(2 Suppl):145-158. DOI: https://doi.org/10.26355/eurrev_201904_17484
Gornitzky AL, Kim AE, O'Donnell JM, Swarup I. Diagnosis and management of osteomyelitis in children: a critical analysis review. JBJS Rev [Internet]. 2020 jun. [Citado 01 May 2023]; 8(6):e1900202. DOI: https://doi.org/10.2106/JBJS.RVW.19.00202
Sybenga AB, Jupiter DC, Speights VO, Rao A. Diagnosing osteomyelitis: a histology guide for pathologists. J Foot Ankle Surg [Internet]. 2020 jan-feb. [Citado 26 Jun 2023]; 59(1):75-85. DOI: https://doi.org/10.1053/j.jfas.2019.06.007
Massel DH, Jenkins NW, Rush AJ 3rd, Trapana JE, Foremny GB, Donnally CJ 3rd, et al. MRI and clinical risk indicators for osteomyelitis. Foot Ankle Spec [Internet]. 2021 oct. [Citado 26 Jun 2023]; 14(5):415-426. DOI: https://doi.org/10.1177/1938640020921572
Snyder B, Schmitt TM. Pediatric Osteomyelitis: a case report. J Ped Health Care [Internet]. 2020 sep-oct. [Citado 26 Jun 2023];34(5):478-480. DOI: https://doi.org/10.1016/j.pedhc.2020.06.002
Otani Y, Aizawa Y, Hataya H, Horikoshi Y. Diagnostic errors in pediatric bacterial osteomyelitis. Pediatr Int [Internet]. 2019 oct. [Citado 26 Jun 2023]; 61(10):988-993. DOI: https://doi.org/10.1111/ped.13979
Bor N, Dujovny E, Rinat B, Rozen N, Rubin G. Treatment of chronic osteomyelitis with antibiotic-impregnated polymethyl methacrylate (PMMA) - the Cierny approach: is the second stage necessary? BMC Musculoskelet Disord [Internet]. 2022 jan. [Citado 26 Jun 2023]; 23(1):38. DOI: https://doi.org/10.1186/s12891-021-04979-y
Hofstee MI, Muthukrishnan G, Atkins GJ, Riool M, Thompson K, Morgenstern M, et al. Current concepts of osteomyelitis: from pathologic mechanisms to advanced research methods. Am J Pathol [Internet]. 2020 Jun [Citado 26 Jun 2023]; 190(6):1151-1163. DOI: https://doi.org/10.1016/j.ajpath.2020.02.007
Munshi B, MacFater W, Hill AG, McCaig EH. Paediatric osteomyelitis in Fiji. World J Surg [Internet]. 2018 dec. [Citado 26 Jun 2023]; 42(12):4118-4122. DOI: https://doi.org/10.1007/s00268-018-4743-2
Nadau E, Joseph C, Haraux E, Deroussen F, Gouron R, Klein C. Clinical features and outcomes in children with bone and joint infections of the ankle or foot. Arch Ped [Internet]. 2020 nov. [Citado 26 Jun 2023]; 27(8):464-468. DOI: https://doi.org/10.1016/j.arcped.2020.08.005
Taylor TN, Bridges CS, Ezeokoli EU, Smith TS, Montgomery NI. Retrospective review of 80 patients with chronic recurrent multifocal osteomyelitis evaluated by pediatric orthopaedic surgeons. JPOSNA [Internet]. 2023 feb. [Citado 26 Jun 2023]; 5(1):1-11. DOI: https://doi.org/10.55275/JPOSNA-2023-575
Kyler KE, Lee BR, Glynn EF, Waddell JP, Hoffman MA, Goldman JL. Clinical outcome and antibiotic dosing differences by weight in children with acute osteomyelitis. Hosp Pediatr [Internet]. 2021 oct. [Citado 26 Jun 2023]; 11(10):1112-1120. DOI: https://doi.org/10.1542/hpeds.2021-005890
Disch K, Hill DA, Snow H, Dehority W. Clinical outcomes of pediatric osteomyelitis. BMC Ped [Internet]. 2023 feb. [Citado 26 Jun 2023]; 23(1):54. DOI: https://doi.org/10.1186/s12887-023-03863-z
Krysztofiak A, Roversi M, Musolino A, Cirillo M, Toniolo RM, Mazza O, et al. Clinical report and predictors of sequele of 319 cases of pediatric bacterial osteomyelitis. Sciet Rep [Internet]. 2022 [Citado 26 Jun 2023]; 12:14846. DOI: https://doi.org/10.1038/s41598-022-19208-2
Février A, Boursot C, Tannugi KC. Osteomyelitis and gentamicin-PMMA chains. Clin Nucl Med [Internet]. 2022 nov. [Citado 26 Jun 2023]; 47(11):e708-e709. Disponible en: https://doi.org/10.1097/RLU.0000000000004360
Lazzeri S, Montagnani C, Zanardi A, Beltrami G, Galli L. Bioactive glass in the treatment of chronic osteomyelitis in children: description of four consecutive cases and literature review. Injury [Internet]. 2022 oct. [Citado 26 Jun 2023]; 53(10):3317-3321. DOI: https://doi.org/10.1016/j.injury.2022.07.014
Wu ZQ, Zeng DL, Yao JL, Bian YY, Gu YT, Meng ZL, et al. Research progress on diagnosis and treatment of chronic osteomyelitis. Chin Med Sci J [Internet]. 2019 sep. [Citado 26 Jun 2023]; 34(3):211-220. DOI: https://doi.org/10.24920/003493
Sergi CM, Miller E, Demellawy DE, Shen F, Zhang M. Chronic recurrent multifocal osteomyelitis. A narrative and pictorial review. Front Immunol [Internet]. 2022 aug. [Citado 26 Jun 2023]; 13:959575. DOI: https://doi.org/10.3389/fimmu.2022.959575
Copley LAB. Infections of the musculoskeletal system. En: Herring JA. Tachdjian's Pediatric Orthopaedics. 6ed. Philadelphia: Elsevier; 2022. p:945-994.
Dabov GD. Osteomyelitis. En: Azar FM, Beaty JH. Campbell's Operative Orthopaedics. 14 ed. Philadelphia: Elsevier; 2021. p:817-839.
Wen Y, Wang C, Jia H, Liu T, Yu J, Zhang M. Comparison of diagnosis and treatment of MSSA and MRSA osteomyelitis in children: a case control study of 64 patients. J Orthop Sur Res [Internet]. 2023 [Citado 26 Jun 2023]; 18:197. DOI: https://doi.org/10.1186/s13018-023-03670-3
Nasser A, Azimi T, Ostadmohammadi S, Ostadmohammadi S. A comprehensive review of bacterial osteomyelitis with emphasis on Staphylococcus aureus. Microb Pathog [Internet]. 2020 nov. [Citado 26 Jun 2023]; 148:104431. Disponible en: https://doi.org/10.1016/j.micpath.2020.104431
Masters EA, Ricciardi BF, Bentley KLM, Moriarty TF, Schwarz EM, Muthukrishnan G. Skeletal infections: microbial pathogenesis, immunity and clinical management. Nat Rev Microbiol [Internet]. 2022 jul. [Citado 26 Jun 2023]; 20(7):385-400. DOI: https://doi.org/10.1038/s41579-022-00686-0
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Copyright (c) 2024 Alejandro Alvarez López, Valentina Valdebenito-Aceitón, Sergio Ricardo Soto-Carrasco, Yenima de la Caridad García Lorenzo

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