Influence of periodontal disease on aterosclerosis
DOI:
https://doi.org/10.5281/zenodo.10440404Keywords:
atherosclerosis, periodontal disease, risk factor, periodontitisAbstract
Introduction: periodontal disease has been identified as a risk factor for heart disease. The lack of oral hygiene habits associated with risk factors can lead to the development of periodontitis, which will lead to an increase in inflammatory mediators in the blood, which is a potential risk for the development of the atherosclerosis process. Objective: to evaluate in the literature the influence of periodontal disease on cardiovascular diseases, especially in relation to atherosclerosis. Method: it consisted of a search in books and scientific articles, with the use of associated keywords, as well as selected articles in the SciELO, PubMed, Scopus databases, from which around 40 bibliographies were obtained, which were narrowed down to 35, of them 50% updated. Results: meta-analysis studies support a causal relationship between periodontal disease and heart disease, demonstrating that the risk of developing some vascular complications was found to be increased in patients with periodontal problems. Final considerations: it is relevant to evaluate the relationship between these diseases and the mechanisms involved, in order to develop preventive measures.
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References
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8. Amar S, et al. Periodontal Disease Is Associated With Brachial Artery Endothelial Dysfunction and Systemic Inflammation. Arterios Thromb Vasc Bio [Internet]. 2003 [citado 15 Sept 2023]; 23(7):1245-1249 DOI: https://doi.org/10.1161/01.atv.0000078603.90302.4a
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11. Kozarov E, et al. Detection of bacterial DNA in atheromatous plaques by quantitative PCR. Microb Infect [Internet]. 2006 [citado 15 Sept 2023]; 8(3):687-693 DOI: https://doi.org/10.1016/j.micinf.2005.09.004
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16. Carranza FA, et al. Periodontología Clínica. 11na ed. Colombia: Amolca; 2014.
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19. Cortés-Vieyra R, Rosales C, Uribe-Querol E. Neutrophil Functions in Periodontal Homeostasis. J Immun Resear [Internet]. 2016 [citado 15 Sept 2023]; 2016:1-9 DOI: https://doi.org/10.1155/2016/1396106
20. Nazir M, Al-Ansari A, Al-Khalifa K, Alhareky M, Gaffar B, Almas K. Global Prevalence of Periodontal Disease and Lack of Its Surveillance. Scient World J [Internet]. 2020 [citado 15 Sept 2023]; 2020:1-8 DOI: https://doi.org/10.1155/2020/2146160
21. Abiko, et al. Profiling of subgingival plaque biofilm microflora from periodontally healthy subjects and from subjects with periodontitis using quantitative real-time PCR. J Period Resear [Internet]. 2010 [citado 15 Sept 2023]; 45(3):389-395 DOI: https://doi.org/10.1111/j.1600-0765.2009.01250.x
22. Bogliolo L, Brasileiro Filho G. Patologia. 9na ed. Rio de Janeiro: Guanabara Koogan; 2016.
23. Tabas I, García-cardeña G, Owens GK. Recent insights into the cellular biology of atherosclerosis. J Cell Biol [Internet]. 2015 [citado 15 Sept 2023]; 209(1):13-22 DOI: https://doi.org/10.1083/jcb.201412052
24. Lockhart PB, Bolger AF, Papapanou PN, Osinbowale O, Trevisan M, Levison ME, Baddour LM. Periodontal disease and atherosclerotic vascular disease: does the evidence support an independent association? A scientific statement from the American Heart Association. Circulation [Internet]. 2012 [citado 15 Sept 2023]; 125(20):2520-2544 DOI: https://doi.org/10.1161/CIR.0b013e31825719f3
25. Chistiakov DA, Orekhov AN, Bobryshev YV. Links between atherosclerotic and periodontal disease. Exper Molec Pathol [Internet]. 2016 [citado 15 Sept 2023]; 100(1):220-235 DOI: https://doi.org/10.1016/j.yexmp.2016.01.006
26. Graves DT, Jiang Y, Genco C. Periodontal disease: bacterial virulence factors, host response and impact on systemic health. Curr Opin Infect Disea [Internet]. 2000 [citado 15 Sept 2023]; 13(3):227-232 DOI: https://doi.org/10.1097/00001432-200006000-00005
27. Gaetti-Jardim Jr E, Marcelino SL, Feitosa AC, Romito GA, Avila-Campos MJ. Quantitative detection of periodontopathic bacteria in atherosclerotic plaques from coronary arteries. J Med Microbiol [Internet]. 2009 [citado 15 Sept 2023]; 58(12):1568-1575 DOI: https://doi.org/10.1099/jmm.0.013383-0
28. Olsen I. Update on bacteraemia related to dental procedures. Transf Apher Scien [Internet]. 2008 [citado 15 Sept 2023]; 39(2):173-178 DOI: https://doi.org/10.1016/j.transci.2008.06.008
29. Renvert S, Pettersson T, Ohlsson O, Persson GR. Bacterial Profile and Burden of Periodontal Infection in Subjects With a Diagnosis of Acute Coronary Syndrome. J Periodont [Internet]. 2006 [citado 15 Sept 2023]; 77(7):1110-1119 DOI: https://doi.org/10.1902/jop.2006.050336
30. Haraszthy VI, Zambon JJ, Trevisan M, Zeid M, Genco RJ. Identification of periodontal pathogens in atheromatous plaques. J Periodont [Internet], 2000 [citado 15 Sept 2023]; 71(10):1554-1560 DOI: https://doi.org/10.1902/jop.2000.71.10.1554
31. Armingohar Z, Jørgensen JJ, Kristoffersen AK, Abesha-Belay E, Olsen I. Bacteria and bacterial DNA in atherosclerotic plaque and aneurysmal wall biopsies from patients with and without periodontitis. J Oral Microb [Internet]. 2014 [citado 15 Sept 2023]; 6(1):23408 DOI: https://doi.org/10.3402/jom.v6.23408
32. Lindhe J, Thorkild K, Niklaus P Lang. Periodontologia Clínica e Implantología Odontológica. 5ta Ed. Argentina: Ed. Medica Panamericana; 2006.
33. Landzberg M, et al. Quantifying oral inflammatory load: oral neutrophil counts in periodontal health and disease. J Periodon Resear [Internet]. 2014 [citado 15 Sept 2023]; 50(3):330-336 DOI: https://doi.org/10.1111/jre.12211
34. Khoury W, Glogauer J, Tenenbaum HC, Glogauer M. Oral inflammatory load: neutrophils as oral health biomarkers. J Periodon Resear [Internet]. 2020 [citado 15 Sept 2023]; 55(5):594-601 DOI: https://doi.org/10.1111/jre.12758
35. Glurich I, et al. Systemic Inflammation in Cardiovascular and Periodontal Disease: comparative study. Clinic Vaccine Immunol [Internet]. 2002 [citado 15 Sept 2023]; 9(2):425-432 DOI: https://doi.org/10.1128/CDLI.9.2.425-432.2002
36. Pussinen PJ, Mattila K. Periodontal infections and atherosclerosis: mere associations? Current Opin Lipidol [Internet]. 2004 [citado 15 Sept 2023]; 15(5):583-588. DOI: https://doi.org/10.1097/00041433-200410000-00013
37. Katz J, et al. Association Between Periodontal Pockets and Elevated Cholesterol and Low Density Lipoprotein Cholesterol Levels. J Periodont [Internet]. 2002 [citado 15 Sept 2023]; 73(5):494-500 DOI: https://doi.org/10.1902/jop.2002.73.5.494
38. Tonetti MS, D'Aiuto F, Nibali L, Donald A, Storry C, Parkar M, Deanfield J. Treatment of Periodontitis and Endothelial Function. New Eng J Med [Internet]. 2007 [citado 15 Sept 2023]; 356(9):911-920. DOI: https://doi.org/10.1056/nejmoa063186
39. Roca-Millan E, et al. Periodontal treatment on patients with cardiovascular disease: systematic review and meta-analysis. Med Oral Patol Oral Cirug Buc [Internet]. 2018 [citado 15 Sept 2023]; 23(6):e681 DOI: https://doi.org/10.4317/medoral.22725
40. Montenegro MM, et al. Randomized controlled trial of the effect of periodontal treatment on cardiovascular risk biomarkers in patients with stable 40 coronary artery disease: Preliminary findings of 3 months. J Clinic Periodont [Internet]. 2019 [citado 15 Sept 2023]; 46(3):321-331 DOI: https://doi.org/10.1111/jcpe.13085
41. D’Aiuto F, Parkar M, Andreou G, Suvan J, Brett PM, Ready D, Tonetti MS. Periodontitis and systemic inflammation: control of the local infection is associated with a reduction in serum inflammatory markers. J Dental Resear [Internet]. 2004 [citado 15 Sept 2023]; 83(2):156-160. DOI: https://doi.org/10.1177/154405910408300214
42. Ide M, et al. Effect of treatment of chronic periodontitis on levels of serum markers of acute-phase inflammatory and vascular responses. J Clinic Periodont [Internet]. 2003 [citado 15 Sept 2023]; 30(4):334-340 DOI: https://doi.org/10.1034/j.1600-051X.2003.00282.x
43. Priyamvara A, et al. Periodontal Inflammation and the Risk of Cardiovascular Disease. Current Atheros Rep [Internet]. 2020 [citado 15 Sept 2023]; 22(7)1-6 DOI: https://doi.org/10.1007/s11883-020-00848-6
44. Blaizot A, et al. Periodontal diseases and cardiovascular events: meta‐analysis of observational studies. Intern Dent J [Internet]. 2009 [citado 15 Sept 2023]; 59(4):197-209 DOI: https://doi.org/10.1922/IDJ_2114Sixou13
45. Janket SJ, et al. Meta-analysis of periodontal disease and risk of coronary heart disease and stroke. Oral Surg Oral Med Oral Pathol Oral Radiol Endodont [Internet]. 2003 [citado 15 Sept 2023]; 95(5):559-569 DOI: https://doi.org/10.1067/moe.2003.107Get rights and content
46. Van Dyke TE, Thomas E. Pro-resolving mediators in the regulation of periodontal disease. Molec Asp Med [Internet]. 2017 [citado 15 Sept 2023]; 58:21-36 DOI: https://doi.org/10.1016/j.mam.2017.04.006
2. World Health Organization. The top 10 causes of death. www.who.int, 2018. Disponible en: https://www.who.int/news-room/fact-sheets/detail/the-top-10- causes-of-death
3. Fernández-Britto Rodríguez JE, Armisén Penichet A, Bacallao Gallestey J, Piñeiro Lamas R, Ferrer Arrocha M, Alonso Martínez M, et al. Centro de Investigaciones y Referencia de Aterosclerosis de La Habana, otro eslabón de la salud pública cubana. Rev Cubana Salud Púb [Internet]. 2012 [citado 21/09/2023]; 38(2):292-299.. Disponible en: https://www.redalyc.org/articulo.oa?id=21422359013
4. Hamilton JA, et al. Atherosclerosis, Periodontal Disease, and Treatment with Resolvins. Current Athero Repor [Internet]. 2017 [citado 15 Sept 2023]; 19(12):1-10. Disponible en: https://link.springer.com/article/10.1007/s11883-017-0696-4
5. Behrendt D, Ganz P. Endothelial function: from vascular biology to clinical applications. Am J Cardio [Internet]. 2002 [citado 15 Sept 2023] 90(10):40-48 DOI: https://doi.org/10.1016/S0002-9149(02)02963-6
6. Joshipura KJ, et al. Periodontal Disease and Biomarkers Related to Cardiovascular Disease. J Dent Resear [Internet]. 2004 [citado 15 Sept 2023]; 83(2):151- 155 DOI: https://doi.org/10.1177/154405910408300213
7. Carrizales-Sepúlveda EF, et al. Periodontal Disease, Systemic Inflammation and the Risk of Cardiovascular Disease. Heart Lung Circul [Internet]. 2018 [citado 15 Sept 2023]; 27(11):1327-1334 DOI: https://doi.org/10.1016/j.hlc.2018.05.102
8. Amar S, et al. Periodontal Disease Is Associated With Brachial Artery Endothelial Dysfunction and Systemic Inflammation. Arterios Thromb Vasc Bio [Internet]. 2003 [citado 15 Sept 2023]; 23(7):1245-1249 DOI: https://doi.org/10.1161/01.atv.0000078603.90302.4a
9. Dewhirst Floyd E. et al. The Human Oral Microbiome. J Bacter [Internet]. 2010 [citado 15 Sept 2023]; 192(19):5002-5017. DOI: https://doi.org/10.1128/jb.00542
10. Seymour GJ, et al. Relationship between periodontal infections and systemic disease. Clinic Microb Infect [Internet]. 2007 [citado 15 Sept 2023]; 13:3-10 DOI: https://doi.org/10.1111/j.1469-0691.2007.01798.x
11. Kozarov E, et al. Detection of bacterial DNA in atheromatous plaques by quantitative PCR. Microb Infect [Internet]. 2006 [citado 15 Sept 2023]; 8(3):687-693 DOI: https://doi.org/10.1016/j.micinf.2005.09.004
12. Nilsson Jan, Hansson Göran K, Shah Prediman K. Immunomodulation of Atherosclerosis: implications for vaccine development. Arterios Thromb Vascul Bio. 2005 [citado 15 Sept 2023] 25(1)18-28 DOI: https://doi.org/10.1161/01.ATV.0000149142.42590.a2
13. Tonetti MS, D'Aiuto F, Nibali L, Donald A, Storry C, Parkar M, Suvan J, Hingorani AD, Vallance P, Deanfield J. Treatment of Periodontitis and Endothelial Function. New Engl J Med [Internet]. 2007 [citado 15 Sept 2023]; 356(9):911-920 DOI: https://doi.org/10.1056/NEJMoa063186
14. Nazir MA. Prevalence of periodontal disease, its association with systemic diseases and prevention. Int J Health Sci (Qassim) [Internet]. 2017 [citado 15 Sept 2023]; 11(2):72-80 Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426403/
15. Tonetti M, et al. Primary and secondary prevention of periodontal and peri-implant diseases. J Clin Periodont [Internet]. 2015 [citado 15 Sept 2023]; 42:1-4 DOI: https://doi.org/10.1111/jcpe.12382
16. Carranza FA, et al. Periodontología Clínica. 11na ed. Colombia: Amolca; 2014.
17. Takahashi, Nobuhiro. Microbial ecosystem in the oral cavity: metabolic diversity in an ecological niche and its relationship with oral diseases. 2005 [citado 15 Sept 2023]; 1284:103-112 DOI: https://doi.org/10.1016/j.ics.2005.06.071
18. Kinane Denis F, Stathopoulou Panagiota G, Papapanou Panos N. Periodontal diseases. Nat Reviews Dis Prim [Internet]. 2017 [citado 15 Sept 2023]; 3(1):1-14 DOI: https://doi.org/10.1038/nrdp.2017.38
19. Cortés-Vieyra R, Rosales C, Uribe-Querol E. Neutrophil Functions in Periodontal Homeostasis. J Immun Resear [Internet]. 2016 [citado 15 Sept 2023]; 2016:1-9 DOI: https://doi.org/10.1155/2016/1396106
20. Nazir M, Al-Ansari A, Al-Khalifa K, Alhareky M, Gaffar B, Almas K. Global Prevalence of Periodontal Disease and Lack of Its Surveillance. Scient World J [Internet]. 2020 [citado 15 Sept 2023]; 2020:1-8 DOI: https://doi.org/10.1155/2020/2146160
21. Abiko, et al. Profiling of subgingival plaque biofilm microflora from periodontally healthy subjects and from subjects with periodontitis using quantitative real-time PCR. J Period Resear [Internet]. 2010 [citado 15 Sept 2023]; 45(3):389-395 DOI: https://doi.org/10.1111/j.1600-0765.2009.01250.x
22. Bogliolo L, Brasileiro Filho G. Patologia. 9na ed. Rio de Janeiro: Guanabara Koogan; 2016.
23. Tabas I, García-cardeña G, Owens GK. Recent insights into the cellular biology of atherosclerosis. J Cell Biol [Internet]. 2015 [citado 15 Sept 2023]; 209(1):13-22 DOI: https://doi.org/10.1083/jcb.201412052
24. Lockhart PB, Bolger AF, Papapanou PN, Osinbowale O, Trevisan M, Levison ME, Baddour LM. Periodontal disease and atherosclerotic vascular disease: does the evidence support an independent association? A scientific statement from the American Heart Association. Circulation [Internet]. 2012 [citado 15 Sept 2023]; 125(20):2520-2544 DOI: https://doi.org/10.1161/CIR.0b013e31825719f3
25. Chistiakov DA, Orekhov AN, Bobryshev YV. Links between atherosclerotic and periodontal disease. Exper Molec Pathol [Internet]. 2016 [citado 15 Sept 2023]; 100(1):220-235 DOI: https://doi.org/10.1016/j.yexmp.2016.01.006
26. Graves DT, Jiang Y, Genco C. Periodontal disease: bacterial virulence factors, host response and impact on systemic health. Curr Opin Infect Disea [Internet]. 2000 [citado 15 Sept 2023]; 13(3):227-232 DOI: https://doi.org/10.1097/00001432-200006000-00005
27. Gaetti-Jardim Jr E, Marcelino SL, Feitosa AC, Romito GA, Avila-Campos MJ. Quantitative detection of periodontopathic bacteria in atherosclerotic plaques from coronary arteries. J Med Microbiol [Internet]. 2009 [citado 15 Sept 2023]; 58(12):1568-1575 DOI: https://doi.org/10.1099/jmm.0.013383-0
28. Olsen I. Update on bacteraemia related to dental procedures. Transf Apher Scien [Internet]. 2008 [citado 15 Sept 2023]; 39(2):173-178 DOI: https://doi.org/10.1016/j.transci.2008.06.008
29. Renvert S, Pettersson T, Ohlsson O, Persson GR. Bacterial Profile and Burden of Periodontal Infection in Subjects With a Diagnosis of Acute Coronary Syndrome. J Periodont [Internet]. 2006 [citado 15 Sept 2023]; 77(7):1110-1119 DOI: https://doi.org/10.1902/jop.2006.050336
30. Haraszthy VI, Zambon JJ, Trevisan M, Zeid M, Genco RJ. Identification of periodontal pathogens in atheromatous plaques. J Periodont [Internet], 2000 [citado 15 Sept 2023]; 71(10):1554-1560 DOI: https://doi.org/10.1902/jop.2000.71.10.1554
31. Armingohar Z, Jørgensen JJ, Kristoffersen AK, Abesha-Belay E, Olsen I. Bacteria and bacterial DNA in atherosclerotic plaque and aneurysmal wall biopsies from patients with and without periodontitis. J Oral Microb [Internet]. 2014 [citado 15 Sept 2023]; 6(1):23408 DOI: https://doi.org/10.3402/jom.v6.23408
32. Lindhe J, Thorkild K, Niklaus P Lang. Periodontologia Clínica e Implantología Odontológica. 5ta Ed. Argentina: Ed. Medica Panamericana; 2006.
33. Landzberg M, et al. Quantifying oral inflammatory load: oral neutrophil counts in periodontal health and disease. J Periodon Resear [Internet]. 2014 [citado 15 Sept 2023]; 50(3):330-336 DOI: https://doi.org/10.1111/jre.12211
34. Khoury W, Glogauer J, Tenenbaum HC, Glogauer M. Oral inflammatory load: neutrophils as oral health biomarkers. J Periodon Resear [Internet]. 2020 [citado 15 Sept 2023]; 55(5):594-601 DOI: https://doi.org/10.1111/jre.12758
35. Glurich I, et al. Systemic Inflammation in Cardiovascular and Periodontal Disease: comparative study. Clinic Vaccine Immunol [Internet]. 2002 [citado 15 Sept 2023]; 9(2):425-432 DOI: https://doi.org/10.1128/CDLI.9.2.425-432.2002
36. Pussinen PJ, Mattila K. Periodontal infections and atherosclerosis: mere associations? Current Opin Lipidol [Internet]. 2004 [citado 15 Sept 2023]; 15(5):583-588. DOI: https://doi.org/10.1097/00041433-200410000-00013
37. Katz J, et al. Association Between Periodontal Pockets and Elevated Cholesterol and Low Density Lipoprotein Cholesterol Levels. J Periodont [Internet]. 2002 [citado 15 Sept 2023]; 73(5):494-500 DOI: https://doi.org/10.1902/jop.2002.73.5.494
38. Tonetti MS, D'Aiuto F, Nibali L, Donald A, Storry C, Parkar M, Deanfield J. Treatment of Periodontitis and Endothelial Function. New Eng J Med [Internet]. 2007 [citado 15 Sept 2023]; 356(9):911-920. DOI: https://doi.org/10.1056/nejmoa063186
39. Roca-Millan E, et al. Periodontal treatment on patients with cardiovascular disease: systematic review and meta-analysis. Med Oral Patol Oral Cirug Buc [Internet]. 2018 [citado 15 Sept 2023]; 23(6):e681 DOI: https://doi.org/10.4317/medoral.22725
40. Montenegro MM, et al. Randomized controlled trial of the effect of periodontal treatment on cardiovascular risk biomarkers in patients with stable 40 coronary artery disease: Preliminary findings of 3 months. J Clinic Periodont [Internet]. 2019 [citado 15 Sept 2023]; 46(3):321-331 DOI: https://doi.org/10.1111/jcpe.13085
41. D’Aiuto F, Parkar M, Andreou G, Suvan J, Brett PM, Ready D, Tonetti MS. Periodontitis and systemic inflammation: control of the local infection is associated with a reduction in serum inflammatory markers. J Dental Resear [Internet]. 2004 [citado 15 Sept 2023]; 83(2):156-160. DOI: https://doi.org/10.1177/154405910408300214
42. Ide M, et al. Effect of treatment of chronic periodontitis on levels of serum markers of acute-phase inflammatory and vascular responses. J Clinic Periodont [Internet]. 2003 [citado 15 Sept 2023]; 30(4):334-340 DOI: https://doi.org/10.1034/j.1600-051X.2003.00282.x
43. Priyamvara A, et al. Periodontal Inflammation and the Risk of Cardiovascular Disease. Current Atheros Rep [Internet]. 2020 [citado 15 Sept 2023]; 22(7)1-6 DOI: https://doi.org/10.1007/s11883-020-00848-6
44. Blaizot A, et al. Periodontal diseases and cardiovascular events: meta‐analysis of observational studies. Intern Dent J [Internet]. 2009 [citado 15 Sept 2023]; 59(4):197-209 DOI: https://doi.org/10.1922/IDJ_2114Sixou13
45. Janket SJ, et al. Meta-analysis of periodontal disease and risk of coronary heart disease and stroke. Oral Surg Oral Med Oral Pathol Oral Radiol Endodont [Internet]. 2003 [citado 15 Sept 2023]; 95(5):559-569 DOI: https://doi.org/10.1067/moe.2003.107Get rights and content
46. Van Dyke TE, Thomas E. Pro-resolving mediators in the regulation of periodontal disease. Molec Asp Med [Internet]. 2017 [citado 15 Sept 2023]; 58:21-36 DOI: https://doi.org/10.1016/j.mam.2017.04.006
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2023-12-21
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Miranda-Anchundia AK, Valbuena-Salazar GA, Zambrano-Salazar DF, Legrá-Terrero M. Influence of periodontal disease on aterosclerosis. Rev Inf Cient [Internet]. 2023 Dec. 21 [cited 2025 Apr. 3];102:4422. Available from: https://revinfcientifica.sld.cu/index.php/ric/article/view/4422
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