Influência da doença periodontal na aterosclerose
DOI:
https://doi.org/10.5281/zenodo.10440404Palavras-chave:
aterosclerose, doença periodontal, fator de risco, periodontiteResumo
Introdução: a doença periodontal tem sido apontada como fator de risco para doenças cardíacas. A falta de hábitos de higiene bucal associada a fatores de risco pode levar ao desenvolvimento de periodontite, o que levará ao aumento de mediadores inflamatórios no sangue, o que representa um risco potencial para o desenvolvimento do processo de aterosclerose. Objetivo: avaliar na literatura a influência da doença periodontal nas doenças cardiovasculares, principalmente em relação à aterosclerose. Método: consistiu na busca em livros e artigos científicos, com utilização de palavras-chave associadas, bem como em artigos selecionados nas bases de dados SciELO, PubMed, Scopus, dos quais foram obtidas cerca de 40 bibliografias, que foram reduzidas a 35, de eles 50% atualizados. Resultados: estudos de meta-análise apoiam uma relação causal entre doença periodontal e doença cardíaca, demonstrando que o risco de desenvolver algumas complicações vasculares foi aumentado em pacientes com problemas periodontais. Considerações finais: é relevante avaliar a relação entre estas doenças e os mecanismos envolvidos, para desenvolver medidas preventivas.
Downloads
Referências
Kinane DF. Causation and pathogenesis of periodontal disease. Periodontology 2000 [Internet]. 2001 [citado 21 Sept 2023]; 25(1):8-20. Disponible en: https://shorturl.at/xAO04
World Health Organization. The top 10 causes of death. www.who.int, 2018. Disponible en: https://www.who.int/news-room/fact-sheets/detail/the-top-10- causes-of-death
Fernández-Britto Rodríguez JE, Armisén Penichet A, Bacallao Gallestey J, Piñeiro Lamas R, Ferrer Arrocha M, Alonso Martínez M, et al. Centro de Investigaciones y Referencia de Aterosclerosis de La Habana, otro eslabón de la salud pública cubana. Rev Cubana Salud Púb [Internet]. 2012 [citado 21/09/2023]; 38(2):292-299. Disponible en: https://www.redalyc.org/articulo.oa?id=21422359013
Hamilton JA, et al. Atherosclerosis, Periodontal Disease, and Treatment with Resolvins. Current Athero Repor [Internet]. 2017 [citado 15 Sept 2023]; 19(12):1-10. Disponible en: https://link.springer.com/article/10.1007/s11883-017-0696-4
Behrendt D, Ganz P. Endothelial function: from vascular biology to clinical applications. Am J Cardio [Internet]. 2002 [citado 15 Sept 2023] 90(10):40-48 DOI: https://doi.org/10.1016/S0002-9149(02)02963-6
Joshipura KJ, et al. Periodontal Disease and Biomarkers Related to Cardiovascular Disease. J Dent Resear [Internet]. 2004 [citado 15 Sept 2023]; 83(2):151- 155 DOI: https://doi.org/10.1177/154405910408300213
Carrizales-Sepúlveda EF, et al. Periodontal Disease, Systemic Inflammation and the Risk of Cardiovascular Disease. Heart Lung Circul [Internet]. 2018 [citado 15 Sept 2023]; 27(11):1327-1334 DOI: https://doi.org/10.1016/j.hlc.2018.05.102
Amar S, et al. Periodontal Disease Is Associated With Brachial Artery Endothelial Dysfunction and Systemic Inflammation. Arterios Thromb Vasc Bio [Internet]. 2003 [citado 15 Sept 2023]; 23(7):1245-1249 DOI: https://doi.org/10.1161/01.atv.0000078603.90302.4a
Dewhirst Floyd E. et al. The Human Oral Microbiome. J Bacter [Internet]. 2010 [citado 15 Sept 2023]; 192(19):5002-5017. DOI: https://doi.org/10.1128/jb.00542
Seymour GJ, et al. Relationship between periodontal infections and systemic disease. Clinic Microb Infect [Internet]. 2007 [citado 15 Sept 2023]; 13:3-10 DOI: https://doi.org/10.1111/j.1469-0691.2007.01798.x
Kozarov E, et al. Detection of bacterial DNA in atheromatous plaques by quantitative PCR. Microb Infect [Internet]. 2006 [citado 15 Sept 2023]; 8(3):687-693 DOI: https://doi.org/10.1016/j.micinf.2005.09.004
Nilsson Jan, Hansson Göran K, Shah Prediman K. Immunomodulation of Atherosclerosis: implications for vaccine development. Arterios Thromb Vascul Bio. 2005 [citado 15 Sept 2023] 25(1)18-28 DOI: https://doi.org/10.1161/01.ATV.0000149142.42590.a2
Tonetti MS, D'Aiuto F, Nibali L, Donald A, Storry C, Parkar M, Suvan J, Hingorani AD, Vallance P, Deanfield J. Treatment of Periodontitis and Endothelial Function. New Engl J Med [Internet]. 2007 [citado 15 Sept 2023]; 356(9):911-920 DOI: https://doi.org/10.1056/NEJMoa063186
Nazir MA. Prevalence of periodontal disease, its association with systemic diseases and prevention. Int J Health Sci (Qassim) [Internet]. 2017 [citado 15 Sept 2023]; 11(2):72-80 Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426403/
Tonetti M, et al. Primary and secondary prevention of periodontal and peri-implant diseases. J Clin Periodont [Internet]. 2015 [citado 15 Sept 2023]; 42:1-4 DOI: https://doi.org/10.1111/jcpe.12382
Carranza FA, et al. Periodontología Clínica. 11na ed. Colombia: Amolca; 2014.
Takahashi, Nobuhiro. Microbial ecosystem in the oral cavity: metabolic diversity in an ecological niche and its relationship with oral diseases. 2005 [citado 15 Sept 2023]; 1284:103-112 DOI: https://doi.org/10.1016/j.ics.2005.06.071
Kinane Denis F, Stathopoulou Panagiota G, Papapanou Panos N. Periodontal diseases. Nat Reviews Dis Prim [Internet]. 2017 [citado 15 Sept 2023]; 3(1):1-14 DOI: https://doi.org/10.1038/nrdp.2017.38
Cortés-Vieyra R, Rosales C, Uribe-Querol E. Neutrophil Functions in Periodontal Homeostasis. J Immun Resear [Internet]. 2016 [citado 15 Sept 2023]; 2016:1-9 DOI: https://doi.org/10.1155/2016/1396106
Nazir M, Al-Ansari A, Al-Khalifa K, Alhareky M, Gaffar B, Almas K. Global Prevalence of Periodontal Disease and Lack of Its Surveillance. Scient World J [Internet]. 2020 [citado 15 Sept 2023]; 2020:1-8 DOI: https://doi.org/10.1155/2020/2146160
Abiko, et al. Profiling of subgingival plaque biofilm microflora from periodontally healthy subjects and from subjects with periodontitis using quantitative real-time PCR. J Period Resear [Internet]. 2010 [citado 15 Sept 2023]; 45(3):389-395 DOI: https://doi.org/10.1111/j.1600-0765.2009.01250.x
Bogliolo L, Brasileiro Filho G. Patologia. 9na ed. Rio de Janeiro: Guanabara Koogan; 2016
Tabas I, García-cardeña G, Owens GK. Recent insights into the cellular biology of atherosclerosis. J Cell Biol [Internet]. 2015 [citado 15 Sept 2023]; 209(1):13-22 DOI: https://doi.org/10.1083/jcb.201412052
Lockhart PB, Bolger AF, Papapanou PN, Osinbowale O, Trevisan M, Levison ME, Baddour LM. Periodontal disease and atherosclerotic vascular disease: does the evidence support an independent association? A scientific statement from the American Heart Association. Circulation [Internet]. 2012 [citado 15 Sept 2023]; 125(20):2520-2544 DOI: https://doi.org/10.1161/CIR.0b013e31825719f3
Chistiakov DA, Orekhov AN, Bobryshev YV. Links between atherosclerotic and periodontal disease. Exper Molec Pathol [Internet]. 2016 [citado 15 Sept 2023]; 100(1):220-235 DOI: https://doi.org/10.1016/j.yexmp.2016.01.006
Graves DT, Jiang Y, Genco C. Periodontal disease: bacterial virulence factors, host response and impact on systemic health. Curr Opin Infect Disea [Internet]. 2000 [citado 15 Sept 2023]; 13(3):227-232 DOI: https://doi.org/10.1097/00001432-200006000-00005
Gaetti-Jardim Jr E, Marcelino SL, Feitosa AC, Romito GA, Avila-Campos MJ. Quantitative detection of periodontopathic bacteria in atherosclerotic plaques from coronary arteries. J Med Microbiol [Internet]. 2009 [citado 15 Sept 2023]; 58(12):1568-1575 DOI: https://doi.org/10.1099/jmm.0.013383-0
Olsen I. Update on bacteraemia related to dental procedures. Transf Apher Scien [Internet]. 2008 [citado 15 Sept 2023]; 39(2):173-178 DOI: https://doi.org/10.1016/j.transci.2008.06.008
Renvert S, Pettersson T, Ohlsson O, Persson GR. Bacterial Profile and Burden of Periodontal Infection in Subjects With a Diagnosis of Acute Coronary Syndrome. J Periodont [Internet]. 2006 [citado 15 Sept 2023]; 77(7):1110-1119 DOI: https://doi.org/10.1902/jop.2006.050336
Haraszthy VI, Zambon JJ, Trevisan M, Zeid M, Genco RJ. Identification of periodontal pathogens in atheromatous plaques. J Periodont [Internet], 2000 [citado 15 Sept 2023]; 71(10):1554-1560 DOI: https://doi.org/10.1902/jop.2000.71.10.1554
Armingohar Z, Jørgensen JJ, Kristoffersen AK, Abesha-Belay E, Olsen I. Bacteria and bacterial DNA in atherosclerotic plaque and aneurysmal wall biopsies from patients with and without periodontitis. J Oral Microb [Internet]. 2014 [citado 15 Sept 2023]; 6(1):23408 DOI: https://doi.org/10.3402/jom.v6.23408
Lindhe J, Thorkild K, Niklaus P Lang. Periodontologia Clínica e Implantología Odontológica. 5ta Ed. Argentina: Ed. Medica Panamericana; 2006.
Landzberg M, et al. Quantifying oral inflammatory load: oral neutrophil counts in periodontal health and disease. J Periodon Resear [Internet]. 2014 [citado 15 Sept 2023]; 50(3):330-336 DOI: https://doi.org/10.1111/jre.12211
Khoury W, Glogauer J, Tenenbaum HC, Glogauer M. Oral inflammatory load: neutrophils as oral health biomarkers. J Periodon Resear [Internet]. 2020 [citado 15 Sept 2023]; 55(5):594-601 DOI: https://doi.org/10.1111/jre.12758
Glurich I, et al. Systemic Inflammation in Cardiovascular and Periodontal Disease: comparative study. Clinic Vaccine Immunol [Internet]. 2002 [citado 15 Sept 2023]; 9(2):425-432 DOI: https://doi.org/10.1128/CDLI.9.2.425-432.2002
Pussinen PJ, Mattila K. Periodontal infections and atherosclerosis: mere associations? Current Opin Lipidol [Internet]. 2004 [citado 15 Sept 2023]; 15(5):583-588. DOI: https://doi.org/10.1097/00041433-200410000-00013
Katz J, et al. Association Between Periodontal Pockets and Elevated Cholesterol and Low Density Lipoprotein Cholesterol Levels. J Periodont [Internet]. 2002 [citado 15 Sept 2023]; 73(5):494-500 DOI: https://doi.org/10.1902/jop.2002.73.5.494
Tonetti MS, D'Aiuto F, Nibali L, Donald A, Storry C, Parkar M, Deanfield J. Treatment of Periodontitis and Endothelial Function. New Eng J Med [Internet]. 2007 [citado 15 Sept 2023]; 356(9):911-920. DOI: https://doi.org/10.1056/nejmoa063186
Roca-Millan E, et al. Periodontal treatment on patients with cardiovascular disease: systematic review and meta-analysis. Med Oral Patol Oral Cirug Buc [Internet]. 2018 [citado 15 Sept 2023]; 23(6):e681 DOI: https://doi.org/10.4317/medoral.22725
Montenegro MM, et al. Randomized controlled trial of the effect of periodontal treatment on cardiovascular risk biomarkers in patients with stable 40 coronary artery disease: Preliminary findings of 3 months. J Clinic Periodont [Internet]. 2019 [citado 15 Sept 2023]; 46(3):321-331 DOI: https://doi.org/10.1111/jcpe.13085
D’Aiuto F, Parkar M, Andreou G, Suvan J, Brett PM, Ready D, Tonetti MS. Periodontitis and systemic inflammation: control of the local infection is associated with a reduction in serum inflammatory markers. J Dental Resear [Internet]. 2004 [citado 15 Sept 2023]; 83(2):156-160. DOI: https://doi.org/10.1177/154405910408300214
Ide M, et al. Effect of treatment of chronic periodontitis on levels of serum markers of acute-phase inflammatory and vascular responses. J Clinic Periodont [Internet]. 2003 [citado 15 Sept 2023]; 30(4):334-340 DOI: https://doi.org/10.1034/j.1600-051X.2003.00282.x
Priyamvara A, et al. Periodontal Inflammation and the Risk of Cardiovascular Disease. Current Atheros Rep [Internet]. 2020 [citado 15 Sept 2023]; 22(7)1-6 DOI: https://doi.org/10.1007/s11883-020-00848-6
Blaizot A, et al. Periodontal diseases and cardiovascular events: meta‐analysis of observational studies. Intern Dent J [Internet]. 2009 [citado 15 Sept 2023]; 59(4):197-209 DOI: https://doi.org/10.1922/IDJ_2114Sixou13
Janket SJ, et al. Meta-analysis of periodontal disease and risk of coronary heart disease and stroke. Oral Surg Oral Med Oral Pathol Oral Radiol Endodont [Internet]. 2003 [citado 15 Sept 2023]; 95(5):559-569 DOI: https://doi.org/10.1067/moe.2003.107Get rights and content
Van Dyke TE, Thomas E. Pro-resolving mediators in the regulation of periodontal disease. Molec Asp Med [Internet]. 2017 [citado 15 Sept 2023]; 58:21-36 DOI: https://doi.org/10.1016/j.mam.2017.04.006
Downloads
Publicado
Como Citar
Edição
Seção
Licença
Copyright (c) 2023 Andrea Katherin Miranda-Anchundia, Gabriela Alejandra Valbuena-Salazar, Denisse Francisca Zambrano-Salazar, Maryleydis Legrá-Terrero
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
