Potassium ion channels in Camphenol Plus-induced arterial smooth muscle contractile dynamics
Keywords:
ascular smooth muscle, muscle tension, vasodilatation, organ bath, intracanal medication, potassium ions, Camphenol PlusAbstract
Introduction: Camphenol Plus is a chlorophenolic derivative commonly used as an intra – duct medication for pulporadicular treatments in Dentistry. Scientific reports about the use of this medication on the role of potassium ion channels in the contractile dynamics of induced arterial smooth muscle are low.
Objective: to determine the role of potassium ion channels in the contractile dynamics of Camphenol Plus - induced arterial smooth muscle.
Method: a preclinical experimental investigation was performed at the "Oscar Langerdorff" Institute of Physiology, Rostock University Medical Center, Rostock, Germany, between October and December 2018. A total of 30 aortic rings obtained from 10 Wistar rats (n=10) were used. The biological preparations were placed in an organ bath and preactivated with Krebs solution concentrated in potassium ions, afterwards it was recorded the tension developed by the vascular smooth muscle after applying the Camphenol Plus solutions in different time intervals. The Mann-Whitney U test and Wilcoxon test were applied.
Results: the 31.4% of vascular smooth muscle was relaxed by the effect of Camphenol Plus after preactivation with Krebs solution concentrated in potassium ions. The greatest decrease in vascular tone occurred between the first and third minutes after the use of the drug solutions prepared at 7 %.
Conclusions: the in vitro vasorelaxant effect produced by the Camphenol Plus medication on arterial smooth muscle is mediated by the potassium ion channels sensitive to voltage, calcium and the adenosine triphosphate of the vascular endothelium and sarcolemma.
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References
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