Incidence of renal cell carcinoma in Santiago de Cuba
Keywords:
adenocarcinoma, kidney, renal cell carcinoma, incidence, diagnosisAbstract
Introduction: renal parenchymal tumors account for approximately 2-3% of tumors in adults’ patients and in turn the 85% of primary kidney tumors. An increased incidence of renal parenchymal tumors has been observed around the world and in Cuba in the last years. It is the most deadly cancer in the urinary tract worldwide.
Objective: to identify incidence and the clinical-epidemiological and histopathological features of renal cell carcinoma in the province of Santiago de Cuba.
Method: a descriptive and cross-sectional study was conducted concerning renal adenocarcinoma in 88 patients from Santiago de Cuba. Period of study was from January 1, 2012 throughout January 1, 2017. The diagnosis was based on histopathological studies from patients who underwent surgery and died due to this disease. Variables studies were as follow: incidence, age, sex, risk factors, symptoms and signs, histologic type and cancer staging.
Results: it was more frequent between the fifth and sixth decades of life and in males. Smoking was the main risk factor. More than 50 % of cases were diagnosed incidentally and asymptomatically, although symptoms such as flank pain, hematuria, general symptoms and palpable abdominal mass appeared. Clear cell tumor was the histologic variety most affected. They were diagnosed mainly in stage T3a.
Conclusions: family physicians, clinicians, urologists and radiologists are involved in the diagnosis of renal carcinoma, so it is important to be aware of this illness since it can present in the most unsuspected way.
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References
1. Campbell Steven C, Lane Brian R. Tumores Renales Malignos. En: Wein Alan J, et al. Campbell-Walsh Urología. 10maed [Internet]. México: DF; 2015. [citado 16 May 2021]; v.2. p:1431-1509. Disponible en: https://booksmedicos.org/campbell-walsh-urologia-10a-edicion/
2. Calvo Vazquez I, Santander Flores SA, Gonzales Villegas P, Bravo López GM, Yañes Sosa AL, Reyna Blanco I. Nefrectomía radical: incidencia de morbilidad y mortalidad en un hospital de tercer nivel. Rev Mex Uro l [Internet]. 2017 Nov-Dic [citado 16 May 2021]; 77(6):446-452. Disponible en: https://docplayer.es/137750357-Nefrectomia-radical-incidencia-de-morbilidad-y-mortalidad-en-un-hospital-de-tercer-nivel.html
3. Mahdavifar N, Mohammadian M, Ghonchen M, Salehiniya H. Incidence, Mortality and risk factors of Kidney cancer in the world. World Cancer Res J [Internet]. 2018 [citado 16 May 2021]; 5(1):1-9. Disponible en:
https://www.wcrj.net/wp-content/uploads/sites/5/2018/03/e1013-Incidence-Mortality-and-Risk-Factors-of-Kidney-Cancer-in-the-World.pdf
4. Ljungberg B, Albiges L, Abu-Ghanem Y, Bensalah K, Dabestani S, Fernández-Pello S, et al. European Association of Urology Guidelines on Renal Cell Carcinoma: The 2019 Update Eur Urol [Internet]. 2019 [citado 16 May 2021]; 75:799-810. DOI: https://doi.org/10.1016/j.eururo.2019.02.011
5. Campbell S, Uzzo R, Allaf M, Bass E, Cadeddu J, Chang A, et al. Renal mass and Localized renal cancer: AUA Guideline. Am Urol Assoc Educ Res [Internet].
2017 [citado 16 Abr 2021]; 1-50. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/28479239
6. Sánchez-Lorenzo IM, Torres-Reyes JE, Espinosa-Rondón L, Alvares-Sánchez IM, Peña-Rodríguez H. Caracterización de variables clínicas y terapéuticas en pacientes con adenocarcinoma de células renales claras. Rev Electrón Dr. Zoilo E. Marinello Vidaurreta [Internet]. 2018 [citado 16 May 2021]; 43(4). Disponible en: http://www.revzoilomarinello.sld.cu/index.php/zmv/article/view/1459
7. Uscanga-Yépez J, Martnez-González A, Segovia-Sandoval K, Barrera-Juárez E, González-Oyervides R. Manifestaciones clínicas y resultados oncológicos del cáncer renal en un hospital del norte de México. Rev Mex Urol [Internet]. 2018 May-Jun [citado 16 May 2021]; 78(3):176-182. DOI: https://doi.org/10.24245/revmexurol.v78i3.1929
8. Cancer of the Kidney and Renal Pelvis - SEER Stat Fact Sheets [Internet]. 2020 Oct [citado 16 May 2021]. Disponible en: http://seer.cancer.gov/statfacts/html/kidrp.html
9. ONEI. Anuario Estadístico de Santiago de Cuba 2016 [Internet]. Santiago de Cuba: Oficina Nacional de Estadísticas e Información; 2017. [citado 16 May 2021]. Disponible en: http://www.onei.gob.cu/sites/default/files/anuario_est_provincial/00_santiago_de_cuba.pdf
10.Montironi R, Cheng L, Scarpelli M, Lopez-Beltran A. Pathology and Genetics: The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours. Eur Uro [Internet]. 2016 Jul [citado 16 May 2021]; 70(1):93-105. Disponible en: https://www.clinicalkey.es/service/content/pdf/watermarked/1-s2.0-S0302283816002062.pdf?locale=es_ES&searchIndex=
11.Motzer RJ, Bolger GB, Boston B, Carducci MA, Fishman M, Hancock SL, et al. Clinical Practice Guidelines in Oncology Kidney Cancer. J Natl Compr Canc Netw [Internet]. 2006 Nov [citado 16 May 2021]; 4(10):1072-81. Disponible en: https://pubmed.ncbi.nlm.nih.gov/19555584/
12.Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, et al. Cancer Incidence and Mortality Worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer [Internet]. 2015 Mar [citado 16 May 2021]; 136(5):E359-86. DOI: https://doi.org/10.1002/ijc.29210
13.Darias Martín JL, Rodríguez Collar TL. Influencia del estadio tumoral inicial en la sobrevida de pacientes con adenocarcinoma renal Rev Cubana Med Mil [Internet]. 2018 [citado 16 May 2021]; 47(1):33-42. Disponible en: http://www.revmedmilitar.sld.cu/index.php/mil/article/view/101
14.García García A, Guerra Román F B, García Morales I. Enucleación simple en el tratamiento de los tumores renales Rev Cubana Urol [Internet]. 2017 [citado 16 May 2021]; 6(1). Disponible en: http://www.revurologia.sld.cu
15.Velis J, et al. Risk models for patients with localized renal cell carcinoma. Actas Urol Esp [Internet]. 2017 [citado 16 May 2021]; 41(9):564-570. DOI: https://doi.org/10.1016/j.acuroe.2017.08.007
16.Gelfond J, et al. Modifiable risk factors to reduce renal cell carcinoma incidence: Insight from the PLCO trial. Urol Oncol [Internet]. Jul 2018 [citado 16 May 2021]; 36(7):340.e1-340.e6. DOI: https://doi.org/10.1016/j.urolonc.2018.04.011
17.Arteche AH. Epidemiología descriptiva y análisis de supervivencia del cáncer de riñón en los hospitales públicos de la Comunidad Autónoma de Madrid Tesis Doctoral. Madrid: Universidad Complutense de Madrid, Facultad de Medicina; 2017 [citado 16 May 2021]. Disponible en: https://eprints.ucm.es/id/eprint/47126/1/T39799.pdf
18.Inamura K. Renal Cell Tumors: Understanding Their Molecular Pathological Epidemiology and the 2016 WHO Classification. Int J Mol Sci [Internet]. 2017 [citado 16 May 2021]; 18(10). DOI: https://dx.doi.org/10.3390%2Fijms18102195
19.Lorente D, Trilla E, Meseguer A, Planas J, Placer J, et al. Revisión sistemática de los factores pronósticos del carcinoma renal. Actas Urol Esp [Internet]. 2017 [citado 16 May 2021]; 41(4):215-225. DOI: http://dx.doi.org/10.1016/j.acuro.2016.08.003
20.Lorente ED, Trilla A, Meseguer J, Arévalo S, et al. Valor de la proteína STAT3c como factor pronóstico en el carcinoma renal de célula clara. Revisión sistemática. Actas Urol Esp [Internet]. 2019 [citado 16 May 2021]; 43(3):118-123. DOI: https://doi.org/10.1016/j.acuro.2018.08.003
21.Clemmensen T, et al. Pathologic and clinical characteristics of early onset renal cell carcinoma. Human Pathology [Internet]. 2018 [citado 16 May 2021]; 74:25-31. DOI: https://doi.org/10.1016/j.humpath.2017.11.005
22.Alevizakos M, Gaitanidis A, Nasioudis D, Msaouel P, Appleman LJ. Sarcomatoid renal cell carcinoma: population-based study of 879 patients. Clin Genitourin Cancer [Internet]. 2019 [citado 16 May 2021]; 17:e447-e453. DOI: https://doi.org/10.1016/j.clgc.2019.01.005
23.Prokopowicz G, Kowski M, Nowakowski K, Bogacki R, Bryniarski P, Paradysz A. Basic Parameters of Blood Count as Prognostic Factors for Renal Cell Carcinoma. Bio Med Res Int [Internet]. 2016 [citado 30 Nov 2021]: 8687575. Disponible en: https://www.hindawi.com/journals/bmri/2016/8687575/
2. Calvo Vazquez I, Santander Flores SA, Gonzales Villegas P, Bravo López GM, Yañes Sosa AL, Reyna Blanco I. Nefrectomía radical: incidencia de morbilidad y mortalidad en un hospital de tercer nivel. Rev Mex Uro l [Internet]. 2017 Nov-Dic [citado 16 May 2021]; 77(6):446-452. Disponible en: https://docplayer.es/137750357-Nefrectomia-radical-incidencia-de-morbilidad-y-mortalidad-en-un-hospital-de-tercer-nivel.html
3. Mahdavifar N, Mohammadian M, Ghonchen M, Salehiniya H. Incidence, Mortality and risk factors of Kidney cancer in the world. World Cancer Res J [Internet]. 2018 [citado 16 May 2021]; 5(1):1-9. Disponible en:
https://www.wcrj.net/wp-content/uploads/sites/5/2018/03/e1013-Incidence-Mortality-and-Risk-Factors-of-Kidney-Cancer-in-the-World.pdf
4. Ljungberg B, Albiges L, Abu-Ghanem Y, Bensalah K, Dabestani S, Fernández-Pello S, et al. European Association of Urology Guidelines on Renal Cell Carcinoma: The 2019 Update Eur Urol [Internet]. 2019 [citado 16 May 2021]; 75:799-810. DOI: https://doi.org/10.1016/j.eururo.2019.02.011
5. Campbell S, Uzzo R, Allaf M, Bass E, Cadeddu J, Chang A, et al. Renal mass and Localized renal cancer: AUA Guideline. Am Urol Assoc Educ Res [Internet].
2017 [citado 16 Abr 2021]; 1-50. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/28479239
6. Sánchez-Lorenzo IM, Torres-Reyes JE, Espinosa-Rondón L, Alvares-Sánchez IM, Peña-Rodríguez H. Caracterización de variables clínicas y terapéuticas en pacientes con adenocarcinoma de células renales claras. Rev Electrón Dr. Zoilo E. Marinello Vidaurreta [Internet]. 2018 [citado 16 May 2021]; 43(4). Disponible en: http://www.revzoilomarinello.sld.cu/index.php/zmv/article/view/1459
7. Uscanga-Yépez J, Martnez-González A, Segovia-Sandoval K, Barrera-Juárez E, González-Oyervides R. Manifestaciones clínicas y resultados oncológicos del cáncer renal en un hospital del norte de México. Rev Mex Urol [Internet]. 2018 May-Jun [citado 16 May 2021]; 78(3):176-182. DOI: https://doi.org/10.24245/revmexurol.v78i3.1929
8. Cancer of the Kidney and Renal Pelvis - SEER Stat Fact Sheets [Internet]. 2020 Oct [citado 16 May 2021]. Disponible en: http://seer.cancer.gov/statfacts/html/kidrp.html
9. ONEI. Anuario Estadístico de Santiago de Cuba 2016 [Internet]. Santiago de Cuba: Oficina Nacional de Estadísticas e Información; 2017. [citado 16 May 2021]. Disponible en: http://www.onei.gob.cu/sites/default/files/anuario_est_provincial/00_santiago_de_cuba.pdf
10.Montironi R, Cheng L, Scarpelli M, Lopez-Beltran A. Pathology and Genetics: The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours. Eur Uro [Internet]. 2016 Jul [citado 16 May 2021]; 70(1):93-105. Disponible en: https://www.clinicalkey.es/service/content/pdf/watermarked/1-s2.0-S0302283816002062.pdf?locale=es_ES&searchIndex=
11.Motzer RJ, Bolger GB, Boston B, Carducci MA, Fishman M, Hancock SL, et al. Clinical Practice Guidelines in Oncology Kidney Cancer. J Natl Compr Canc Netw [Internet]. 2006 Nov [citado 16 May 2021]; 4(10):1072-81. Disponible en: https://pubmed.ncbi.nlm.nih.gov/19555584/
12.Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, et al. Cancer Incidence and Mortality Worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer [Internet]. 2015 Mar [citado 16 May 2021]; 136(5):E359-86. DOI: https://doi.org/10.1002/ijc.29210
13.Darias Martín JL, Rodríguez Collar TL. Influencia del estadio tumoral inicial en la sobrevida de pacientes con adenocarcinoma renal Rev Cubana Med Mil [Internet]. 2018 [citado 16 May 2021]; 47(1):33-42. Disponible en: http://www.revmedmilitar.sld.cu/index.php/mil/article/view/101
14.García García A, Guerra Román F B, García Morales I. Enucleación simple en el tratamiento de los tumores renales Rev Cubana Urol [Internet]. 2017 [citado 16 May 2021]; 6(1). Disponible en: http://www.revurologia.sld.cu
15.Velis J, et al. Risk models for patients with localized renal cell carcinoma. Actas Urol Esp [Internet]. 2017 [citado 16 May 2021]; 41(9):564-570. DOI: https://doi.org/10.1016/j.acuroe.2017.08.007
16.Gelfond J, et al. Modifiable risk factors to reduce renal cell carcinoma incidence: Insight from the PLCO trial. Urol Oncol [Internet]. Jul 2018 [citado 16 May 2021]; 36(7):340.e1-340.e6. DOI: https://doi.org/10.1016/j.urolonc.2018.04.011
17.Arteche AH. Epidemiología descriptiva y análisis de supervivencia del cáncer de riñón en los hospitales públicos de la Comunidad Autónoma de Madrid Tesis Doctoral. Madrid: Universidad Complutense de Madrid, Facultad de Medicina; 2017 [citado 16 May 2021]. Disponible en: https://eprints.ucm.es/id/eprint/47126/1/T39799.pdf
18.Inamura K. Renal Cell Tumors: Understanding Their Molecular Pathological Epidemiology and the 2016 WHO Classification. Int J Mol Sci [Internet]. 2017 [citado 16 May 2021]; 18(10). DOI: https://dx.doi.org/10.3390%2Fijms18102195
19.Lorente D, Trilla E, Meseguer A, Planas J, Placer J, et al. Revisión sistemática de los factores pronósticos del carcinoma renal. Actas Urol Esp [Internet]. 2017 [citado 16 May 2021]; 41(4):215-225. DOI: http://dx.doi.org/10.1016/j.acuro.2016.08.003
20.Lorente ED, Trilla A, Meseguer J, Arévalo S, et al. Valor de la proteína STAT3c como factor pronóstico en el carcinoma renal de célula clara. Revisión sistemática. Actas Urol Esp [Internet]. 2019 [citado 16 May 2021]; 43(3):118-123. DOI: https://doi.org/10.1016/j.acuro.2018.08.003
21.Clemmensen T, et al. Pathologic and clinical characteristics of early onset renal cell carcinoma. Human Pathology [Internet]. 2018 [citado 16 May 2021]; 74:25-31. DOI: https://doi.org/10.1016/j.humpath.2017.11.005
22.Alevizakos M, Gaitanidis A, Nasioudis D, Msaouel P, Appleman LJ. Sarcomatoid renal cell carcinoma: population-based study of 879 patients. Clin Genitourin Cancer [Internet]. 2019 [citado 16 May 2021]; 17:e447-e453. DOI: https://doi.org/10.1016/j.clgc.2019.01.005
23.Prokopowicz G, Kowski M, Nowakowski K, Bogacki R, Bryniarski P, Paradysz A. Basic Parameters of Blood Count as Prognostic Factors for Renal Cell Carcinoma. Bio Med Res Int [Internet]. 2016 [citado 30 Nov 2021]: 8687575. Disponible en: https://www.hindawi.com/journals/bmri/2016/8687575/
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Published
2022-01-21
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1.
Rodríguez-Cruzata L. Incidence of renal cell carcinoma in Santiago de Cuba. Rev Inf Cient [Internet]. 2022 Jan. 21 [cited 2025 May 13];101(1):e3545. Available from: https://revinfcientifica.sld.cu/index.php/ric/article/view/3545
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