Caracterización del carcinoma de células escamosas en la cavidad oral
DOI:
https://doi.org/10.5281/zenodo.10955765Keywords:
cavidad oral, células escamosas, carcinoma, factor de riesgo, tratamientoAbstract
Introducción: el carcinoma de células escamosas de la cavidad oral es un problema de salud pública por su alta incidencia a nivel global.
Objetivo: describir los aspectosfundamentales del carcinoma de células escamosas en la cavidad oral.
Desarrollo: se realizó una revisión bibliográfica en PubMed, Scopus, Embase y Web of Science. Se incluyeron estudios observacionales y experimentales publicados en inglés y español en los últimos cinco años, que cumplieron criterios de calidad según la guía STROBE. El carcinoma de células escamosas en la cavidad oral se origina por transformación maligna del epitelio oral mediada por alteraciones genéticas y epigenéticas. Los principales factores de riesgo son el consumo de tabaco y alcohol. El tratamiento depende del estadio y puede incluir cirugía, radioterapia, quimioterapia y terapias dirigidas.
Conclusiones: aunque se han estudiado la fisiopatología, los factores de riesgo y el tratamiento para este cáncer, aún se requiere más investigación sobre biomarcadores, nuevas terapias y factores moleculares asociados a la progresión tumoral, para mejorar la prevención y el manejo de este tipo de cáncer.
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References
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2. Lima CL, Montenegro CR, Pires VR de A, Polignano GAC. Carcinoma de células escamosas do tipo basalóide: um relato de caso raro. stud helth sci [internet]. 2022 jul 11 [cited 11 jun 2024]; 3(3):1298-1306. DOI: https://doi.org/10.54022/shsv3n3-002
3. Bugueño M, Castro S, Cardemil F. Factores de riesgo, etapificación y pronóstico en carcinoma escamoso de cavidad oral. Rev otorrinolaringol cir cabeza cuello [internet]. 2022 Dic [citado 11 jun 2024]; 82(4):476-483. DOI: http://dx.doi.org/10.4067/s0718-48162022000400476
4. Machiels JP, Leemans CR, Golusinski W, Grau C, Licitra L, Gregoire V. Squamous cell carcinoma of the oral cavity, larynx, oropharynx and hypopharynx: ehns-esmo-estro clinical practice guidelines for diagnosis, treatment and follow-up. Ann oncol. [internet]. 2020 nov [citado 15 ene 2024]; 31(11):1462-75. Doi: https://doi.org/10.1016/j.annonc.2020.07.011
5. Page MJ, Mckenzie JE, Bossuyt PM, et al. Declaración prisma 2020: una guía actualizada para la publicación de revisiones sistemáticas. Rev esp cardiol internet]. Sep 2021 [citado 15 ene 2024]; 74(9):790-99. Doi: https://doi.org/10.1016/j.recesp.2021.06.016
6. Von-Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP. The strengthening the reporting of observational studies in epidemiology (strobe) statement: guidelines for reporting observational studies. int j surg internet]. dec 2014 [citado 15 ene 2024]; 12(12):1500-1524. doi: https://doi.org/10.1016/j.ijsu.2014.07.014
7. Melo BAC, Vilar LG, Oliveira NR, Lima PO, Pinheiro MB, Domingueti CP, Pereira MC. Human papillomavirus infection and oral squamous cell carcinoma - a systematic review. Braz j otorhinolaryngol [internet]. 2021 [citado 15 ene 2024]; 87(3):346-352. DOI: https://doi.org/10.1016/j.bjorl.2020.10.017
8. Ding Z, Deng C, Wang Z, Liu L, Ma X, Huang J, Wang X, Xuan M, Xie H. Comparison of contrast-enhanced ultrasound and contrast-enhanced computed tomography for the diagnosis of cervical lymph node metastasis in squamous cell carcinoma of the oral cavity. Int j oral maxillofac surg [internet]. 2021 mar [citado 15 ene 2024];50(3):294-301. DOI: https://doi.org/10.1016/j.ijom.2020.07.013
9. Sundermann BV, Uhlmann L, Hoffmann J, Freier K, Thiele OC. The localization and risk factors of squamous cell carcinoma in the oral cavity: a retrospective study of 1501 cases. J craniomaxillofac surg [internet]. 2018 feb [citado 15 ene 2024]; 46(2):177-182. DOI: https://doi.org/10.1016/j.jcms.2017.10.019
10. Feng L, Houck JR, Lohavanichbutr P, Chen C. Transcriptome analysis reveals differentially expressed lncrnas between oral squamous cell carcinoma and healthy oral mucosa. Oncotarget [internet]. 2017 [citado 15 ene 2024]; 8(19):31521-31531. DOI: https://doi.org/10.18632/oncotarget.16358
11. Kompuinen J, Keskin M, Yilmaz D, Gürsoy M, Gürsoy UK. Human β-defensins in diagnosis of head and neck cancers. Cells [internet]. 2023 [citado 15 ene 2024]; 12(6):830. DOI: https://doi.org/10.3390%2fcells12060830
12. Petruzzi MNMR, Cherubini K, Salum FG, de Figueiredo MAZ. Role of tumour-associated macrophages in oral squamous cells carcinoma progression: an update on current knowledge. Diagn pathol [internet]. 2017 [citado 15 ene 2024]; 12(32). DOI: https://doi.org/10.1186%2fs13000-017-0623-6
13. Mendenhall WM, Holtzman AL, Dagan R, Bryant CM, Hitchcock KE, Amdur RJ, Fernandes RP. Current role of radiotherapy in the management of oral cavity squamous cell carcinoma. Craniomaxillofac trauma reconstr [internet]. 2021 [citado 15 ene 2024];14(1): 79-83. DOI: https://doi.org/10.1177/1943387520971418
14. Karassawa-Zanoni D, Montero PH, Migliacci JC, Shah JP, Wong RJ, Ganly I, Patel SG. Survival outcomes after treatment of cancer of the oral cavity (1985-2015). Oral Oncol [internet]. 2019 Mar [citado 15 Ene 2024]; 90:115-12. DOI: https://doi.org/10.1016/j.oraloncology.2019.02.001
15. Powell SF, Gold KA, Gitau MM, Sumey CJ, et al. Safety and efficacy of pembrolizumab with chemoradiotherapy in locally advanced head and neck squamous cell carcinoma: a phase ib study. J clin oncol [internet]. 2020 [citado 15 ene 2024]; 38(21):2427-2437. DOI: https://doi.org/10.1200/jco.19.03156
16. Sheng-Ping H, Pei-Rung C, Tsung-Ying H, Kai-Ping C, et al. Prognostic significance of the preoperative systemic immune-inflammation index in patients with oral cavity squamous cell carcinoma treated with curative surgery and adjuvant therapy. Cancer med [internet]. 2021 [citado 15 ene 2024]; 10(2):649-658. DOI: https://doi.org/10.1002/cam4.3650
17. Wu-Tong J, Hai-Long M, Tong-Chao Z, et al. Stathmin guides personalized therapy in oral squamous cell carcinoma. Cancer sci [internet]. 2020 [citado 15 ene 2024]; 111(4): 1303-1313. DOI: https://doi.org/10.1111/cas.14323
18. Bramati C, Abati S, Bondi S, Lissoni A, Arrigoni G, Filipello F, Trimarchi M. Early diagnosis of oral squamous cell carcinoma may ensure better prognosis: a case series. Clin case rep [internet]. 2021 oct 25 [citado 15 ene 2024]; 9(10):e05004. DOI: https://doi.org/10.1002/ccr3.5004
19. Lee DS, Ramirez RJ, Lee JJ, Valenzuela CV, Zevallos JP, et al. Survival of young versus old patients with oral cavity squamous cell carcinoma: a meta-analysis. Laryngoscope [internet]. 2021 [citado 15 ene 2024]; 131(6):1310-1319. DOI: https://doi.org/10.1002/lary.29260
20. Patel V, Galloway TJ, Liu JC. The impact of positive margin on survival in oral cavity squamous cell carcinoma. Oral oncol [internet]. 2021 nov [citado 15 ene 2024]; 122: 105499. DOI: https://doi.org/10.1016/j.oraloncology.2021.105499
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Published
2024-07-25
How to Cite
1.
Parreño Gallo VH, Quinaluisa Pazmiño CN, Astudillo Carruyo AJ, Pallo Sarabia MS. Caracterización del carcinoma de células escamosas en la cavidad oral. Rev Inf Cient [Internet]. 2024 Jul. 25 [cited 2025 Apr. 28];103(1 Sup):e4529. Available from: https://revinfcientifica.sld.cu/index.php/ric/article/view/4529
