Síndrome de Kasabach-Merritt esplénico en adulto. Presentación de un caso y revisión del tema
Palabras clave:
Kasabach-Merritt, esplenomegalia, hemangioma esplénico, trombocitopenia, coagulopatía de consumoResumen
Se presentó un paciente de 22 años de edad, masculino, de la raza negra con gran esplenomegalia debido a un hemangioma gigante del bazo, el cual presentó trombocitopenia y trastornos de la coagulación. Se estudió y se diagnosticó un síndrome de Kasabach-Merrit. Se le realizó una esplenectomía total anterior regresando a la normalidad el conteo de plaquetas y los trastornos de la coagulación. Su evolución fue favorable al cabo de los 18 meses de seguimiento. Se recomienda el tratamiento quirúrgico, la esplenectomía. Se revisó el tema por lo infrecuente de la enfermedad.
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Citas
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3. Xu Y, Ouyang J, Zhou M, Xu Y, Li P, Shao X, Chen B, Zhou R. Successful treatment of Kasabach-Merritt syndrome with vindesine: a case report and review of literature. Int J Clin Exp Med [Internet]. 2019 [citado 19 Jul 2020]; 12:125-131. DOI: https://doi.org/10.1177/0300060519830242
4. Make MM, Rajdeo RN, Umap PS, ShrikhandeInt AV. Cavernous haemangioma of spleen: a rare case report. J Res Med Sci [Internet]. 2015 [citado 19 Jul 2020]; 3(8):2132-2134. Disponible en: https://www.msjonline.org/index.php/ijrms/article/view/1670
5. Mitchell RN. Blood Vessels. Hemangiomas. In: Robbins Basic Pathology. 9thed. Philadelphia. Elsevier-Saunders; 2013; p: 358-359.
6. Huang Y, Mu G, Qin X, Lin J, Li S, Zeng Y. 21 cases reports on haemangioma of spleen. J Can Res Ther [Internet]. 2016 [citado 19 Jul 2020]; 12:1323. Disponible en: http://www.cancerjournal.net/text.asp?2016/12/4/1323/199575
7. Willcox T M, Speer R W, Schlinkert R T, Sarr M G. Hemangioma of the spleen: presentation, diagnosis, and management. J Gastrointest Surg [Internet]. 2000 [citado 19 Jul 2020]; 4(6):611-613. Disponible en: https://pubmed.ncbi.nlm.nih.gov/11307096/
8. Huang YH, Zhou DB, Han B, Li T, Wang SJ. Successful treatment of an adult with Kasabach-Merritt syndrome using thalidomide, vincristine, and prednisone. J Int Med Res [Internet]. 2019 [citado 19 Jul 2020]; 47(4):1810-1814. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460612/
9. Karsliolu Y, Çiçek AF, SafalI M, Ifran A, Beyan C. A splenic hemangiomatosis case manifested by Kasabach-Merritt syndrome in an adult. Turkish J Pathol [Internet]. 2008; 24:107-110.
10.Master S, Kallam D, El-Osta H, Peddi P. Clinical Review: Management of Adult Kasabach-Merritt Syndrome Associated with Hemangiomas. J Blood Disord Transfus [Internet]. 2017 [citado 19 Jul 2020]; 8:397. DOI: https://www.doi.org/10.4172/2155-9864.1000397
11.O’Rafferty C, O’Regan GM, Irvine AD, Smith OP. Recent advances in the pathobiology and management of Kasabach–Merritt phenomenon. Brit J Haematol [Internet]. 2015 [citado 19 Jul 2020]; 171:38-51. Disponible en: https://pubmed.ncbi.nlm.nih.gov/26123689/
12.Haque PD, Mahajan A, Chaudhary NK, Jain D. Kasabach-Merritt Syndrome Associated With a Large Cavernous Splenic Hemangioma Treated With Splenectomy: A Surgeon’s Introspection of an Uncommon, Little Read, and Yet Complex Problem-Review Article. Indian J Surg [Internet]. 2015 [citado 19 Jul 2020]; 77(Suppl 1):S166-S169. DOI: https://www.doi.org/10.1007/s12262-015-1232-9
13.Vinod KV, Johny J, Vadivelan M, Hamide A. Kasabach-Merritt Syndrome in an adult. Letter. Turk J Hematol [Internet]. 2018 [citado 19 Jul 2020]; 35:200-216. DOI: https://www.doi.org/10.4274/tjh.2017.0429
14.Abdulrahman AA, Yan J, Hou JS. Kaposiform hemangioendothelioma in an adult spleen: An unusual presentation. Human Pathology: Case Reports [Internet]. 2017 [citado 19 Jul 2020]; 10:15-17. Disponible en: https://www.researchgate.net/publication/317156441_Kaposiform_hemangioendothelioma_in_an_adult_spleen_An_unusual_presentation
15.Lewis D, Vaidya R. Kasabach Merritt Syndrome. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jul [citado 7 Dic 2020]; Disponible en: https://www.ncbi.nlm.nih.gov/books/NBK519053/
2. Rao A, Sharma C, Mohammed S K, Raghuram P. Unusual cause of acute pulmonary thromboembolism: Kasabach merritt Syndrome. J Radiol Med Imag [Internet]. 2018 [citado 19 Jul 2020]; 2:1008-1011. Disponible en: https://meddocsonline.org/journal-of-radiology-and-medical-imaging/unusual-cause-of-acute-pulmonary-thromboembolism-kasabach-merritt-syndrome.html
3. Xu Y, Ouyang J, Zhou M, Xu Y, Li P, Shao X, Chen B, Zhou R. Successful treatment of Kasabach-Merritt syndrome with vindesine: a case report and review of literature. Int J Clin Exp Med [Internet]. 2019 [citado 19 Jul 2020]; 12:125-131. DOI: https://doi.org/10.1177/0300060519830242
4. Make MM, Rajdeo RN, Umap PS, ShrikhandeInt AV. Cavernous haemangioma of spleen: a rare case report. J Res Med Sci [Internet]. 2015 [citado 19 Jul 2020]; 3(8):2132-2134. Disponible en: https://www.msjonline.org/index.php/ijrms/article/view/1670
5. Mitchell RN. Blood Vessels. Hemangiomas. In: Robbins Basic Pathology. 9thed. Philadelphia. Elsevier-Saunders; 2013; p: 358-359.
6. Huang Y, Mu G, Qin X, Lin J, Li S, Zeng Y. 21 cases reports on haemangioma of spleen. J Can Res Ther [Internet]. 2016 [citado 19 Jul 2020]; 12:1323. Disponible en: http://www.cancerjournal.net/text.asp?2016/12/4/1323/199575
7. Willcox T M, Speer R W, Schlinkert R T, Sarr M G. Hemangioma of the spleen: presentation, diagnosis, and management. J Gastrointest Surg [Internet]. 2000 [citado 19 Jul 2020]; 4(6):611-613. Disponible en: https://pubmed.ncbi.nlm.nih.gov/11307096/
8. Huang YH, Zhou DB, Han B, Li T, Wang SJ. Successful treatment of an adult with Kasabach-Merritt syndrome using thalidomide, vincristine, and prednisone. J Int Med Res [Internet]. 2019 [citado 19 Jul 2020]; 47(4):1810-1814. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460612/
9. Karsliolu Y, Çiçek AF, SafalI M, Ifran A, Beyan C. A splenic hemangiomatosis case manifested by Kasabach-Merritt syndrome in an adult. Turkish J Pathol [Internet]. 2008; 24:107-110.
10.Master S, Kallam D, El-Osta H, Peddi P. Clinical Review: Management of Adult Kasabach-Merritt Syndrome Associated with Hemangiomas. J Blood Disord Transfus [Internet]. 2017 [citado 19 Jul 2020]; 8:397. DOI: https://www.doi.org/10.4172/2155-9864.1000397
11.O’Rafferty C, O’Regan GM, Irvine AD, Smith OP. Recent advances in the pathobiology and management of Kasabach–Merritt phenomenon. Brit J Haematol [Internet]. 2015 [citado 19 Jul 2020]; 171:38-51. Disponible en: https://pubmed.ncbi.nlm.nih.gov/26123689/
12.Haque PD, Mahajan A, Chaudhary NK, Jain D. Kasabach-Merritt Syndrome Associated With a Large Cavernous Splenic Hemangioma Treated With Splenectomy: A Surgeon’s Introspection of an Uncommon, Little Read, and Yet Complex Problem-Review Article. Indian J Surg [Internet]. 2015 [citado 19 Jul 2020]; 77(Suppl 1):S166-S169. DOI: https://www.doi.org/10.1007/s12262-015-1232-9
13.Vinod KV, Johny J, Vadivelan M, Hamide A. Kasabach-Merritt Syndrome in an adult. Letter. Turk J Hematol [Internet]. 2018 [citado 19 Jul 2020]; 35:200-216. DOI: https://www.doi.org/10.4274/tjh.2017.0429
14.Abdulrahman AA, Yan J, Hou JS. Kaposiform hemangioendothelioma in an adult spleen: An unusual presentation. Human Pathology: Case Reports [Internet]. 2017 [citado 19 Jul 2020]; 10:15-17. Disponible en: https://www.researchgate.net/publication/317156441_Kaposiform_hemangioendothelioma_in_an_adult_spleen_An_unusual_presentation
15.Lewis D, Vaidya R. Kasabach Merritt Syndrome. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jul [citado 7 Dic 2020]; Disponible en: https://www.ncbi.nlm.nih.gov/books/NBK519053/
Publicado
05-02-2021
Cómo citar
1.
Piriz-Momblant A, Portuondo-Bandera L, Luna-Pérez L. Síndrome de Kasabach-Merritt esplénico en adulto. Presentación de un caso y revisión del tema. Rev Inf Cient [Internet]. 5 de febrero de 2021 [citado 22 de abril de 2025];100(1):e3190. Disponible en: https://revinfcientifica.sld.cu/index.php/ric/article/view/3190
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