Prediction of mortality in patients with severe dengue in the Intensive Care Unit
Keywords:
severe dengue, mortality, predictionAbstract
Introduction: Dengue is an important public health problem for endemic regions. Objective: to identify clinical, biological and imaging variables associated with the probability of dying in patients with severe dengue admitted to the intensive care unit of the General Teaching Hospital "Dr. Agostinho Neto" between January and November 2014. Method: a study was conducted epidemiological, case-control, retrospective study in which all patients were admitted to the research scenario with a diagnosis of severe dengue and whom were confirmed serologically in this studied period. Results:Descriptive statistics and univariate, bivariate and logistic regression were used to determine the association of the selected variables with mortality. It were analyzed 90 cases, 10 deaths and 80 alive. Results: In the univariate analysis, mean blood pressure, urinary output and platelet count, glycaemia, metabolic acidosis and pericardial effusion were found to have significant differences. In the multivariate analysis, that shown an association with mortality, urinary output and mean arterial pressure, glycemia, metabolic acidosis and pericardial effusion. Pericardial effusion and metabolic acidosis have acceptable measures of diagnostic validity and safety of the probability of dying. Conclusions: Mean arterial pressure and urinary output 3, glycemia 2 and 3, metabolic acidosis with DB≥8 mmol / l at time 1 and 2 and pericardial effusion at time 3 were found to be variables with predictive capacity of mortality in patients with severe dengue.Downloads
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References
1. Jiménez Rodríguez O, Suarez Silva N, Junco López M. Caracterización Clínico Epidemiológica del Dengue en Cooperantes Cubanos Estado Trujillo. Diciembre 2008-Diciembre 2009. Arc Hosp Univ "General Calixto García" [Internet]. 2014 [citado 13 Abr 2018]; 2(2):[aprox. 12 p.]. Disponible en: http://www.revcalixto.sld.cu/index.php/ahcg/article/view/56
2. who.int [Internet]. World Health Organization: Global alert and response (GAR): impact of dengue; [actualizado 20 May 2014; citado 19 abr 2018]. Disponible en: www.who.int/csr/disease/dengue/impact/en/index.html
3. Figueroa CL, Gélvez M, Niederbacher J. Reguladores de integridad endotelial como posibles predictores de severidad en dengue. Biomédica [Internet].2016 [citado 13 Abr 2018]; 36(Suppl 2):148-55. Disponible en: http://www.scielo.org.co/pdf/bio/v36s2/v36s2a16.pdf
4. Laiton Donato KD. Análisis de determinantes genéticos de virulencia en cepas del virus dengue tipo 2 [tesis]. Bogotá: Universidad Nacional de Colombia; 2015. Disponible en: http://bdigital.unal.edu.co/51827/7/katherinedlaitond.2015.pdf
5. González DR. Caracterización del dengue hemorrágico en adultos. Epidemia de dengue 3. 2001-2002 [tesis]. Ciudad de La Habana: Instituto de Medicina Tropical “Pedro Kourí”; 2009.
6. Rodríguez Salazara CA, Recalde Reyes DP, González MM, Padilla Sanabria L, Quintero Álvarez L, Gallego Gómez JC, et. al. Manifestaciones clínicas y hallazgos de laboratorio de una serie de casos febriles agudos con diagnóstico presuntivo de infección por el virus dengue. Infectio [Internet].2016 [citado 13 Abr 2018]; 20(2):84-92. Disponible en: https://www.sciencedirect.com/science/article/pii/S0123939215000909
7. Kalayanarooj S, Vaughn DW, Nimmannitya S, Green S, Suntayakorn S, Kunentrasai N. Early clinical and laboratory indicators of acute dengue illness. J Infect Disease [Internet]. 1997 [citado 13 Abr 2018]; 176(2):313-321. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/9237695
8. Laoprasopwattana K, Binsaai J, Pruekprasert P, Geater A.Prothrombin Time Prolongation was the Most Important Indicator of Severe Bleeding in Children with Severe Dengue Viral Infection. J Trop Ped [Internet]. Ago 2017 [citado 13 Abr 2018]; 63(4):[aprox. 6 p.]. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/28177091
9. Meneses Liendo VH. Dengue in critically ill patients. Intensive care unit. Hospital of Pucallpa. Rev Fac Med Hum Univ Ricardo Palma[Internet]. 2013[citado 13 Abr 2018]; 13(1):3-6. Disponible en: http://aulavirtual1.urp.edu.pe/ojs/index.php/RFMH/article/viewFile/160/119
10. Bich Chau TN, Anders KL, Lien LB, Hung NT, MinhHieu LT. Clinical and Virological Features of Dengue in Vietnamese Infants. PLoS Negl Trop Dis [Internet]. 2010 [citado 13 Abr 2018]; 4(4):e657. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/20405057
11. Picollo JF, Oliveira Burdmann EA. Dengue-associated acute kidney injury. Clin Kidney J [Internet]. 2015 [citado 13 Abr 2018]; 8(6):681–685. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655808/
12.Moraes GH, de Fátima Duarte E, Duarte EC. Determinants of mortality from severe dengue in Brazil: a population-based case-control study. Am J Trop Med Hyg [Internet]. 2013 [citado 13 Abr 2018]; 88(4):670-6. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/23400577
2. who.int [Internet]. World Health Organization: Global alert and response (GAR): impact of dengue; [actualizado 20 May 2014; citado 19 abr 2018]. Disponible en: www.who.int/csr/disease/dengue/impact/en/index.html
3. Figueroa CL, Gélvez M, Niederbacher J. Reguladores de integridad endotelial como posibles predictores de severidad en dengue. Biomédica [Internet].2016 [citado 13 Abr 2018]; 36(Suppl 2):148-55. Disponible en: http://www.scielo.org.co/pdf/bio/v36s2/v36s2a16.pdf
4. Laiton Donato KD. Análisis de determinantes genéticos de virulencia en cepas del virus dengue tipo 2 [tesis]. Bogotá: Universidad Nacional de Colombia; 2015. Disponible en: http://bdigital.unal.edu.co/51827/7/katherinedlaitond.2015.pdf
5. González DR. Caracterización del dengue hemorrágico en adultos. Epidemia de dengue 3. 2001-2002 [tesis]. Ciudad de La Habana: Instituto de Medicina Tropical “Pedro Kourí”; 2009.
6. Rodríguez Salazara CA, Recalde Reyes DP, González MM, Padilla Sanabria L, Quintero Álvarez L, Gallego Gómez JC, et. al. Manifestaciones clínicas y hallazgos de laboratorio de una serie de casos febriles agudos con diagnóstico presuntivo de infección por el virus dengue. Infectio [Internet].2016 [citado 13 Abr 2018]; 20(2):84-92. Disponible en: https://www.sciencedirect.com/science/article/pii/S0123939215000909
7. Kalayanarooj S, Vaughn DW, Nimmannitya S, Green S, Suntayakorn S, Kunentrasai N. Early clinical and laboratory indicators of acute dengue illness. J Infect Disease [Internet]. 1997 [citado 13 Abr 2018]; 176(2):313-321. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/9237695
8. Laoprasopwattana K, Binsaai J, Pruekprasert P, Geater A.Prothrombin Time Prolongation was the Most Important Indicator of Severe Bleeding in Children with Severe Dengue Viral Infection. J Trop Ped [Internet]. Ago 2017 [citado 13 Abr 2018]; 63(4):[aprox. 6 p.]. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/28177091
9. Meneses Liendo VH. Dengue in critically ill patients. Intensive care unit. Hospital of Pucallpa. Rev Fac Med Hum Univ Ricardo Palma[Internet]. 2013[citado 13 Abr 2018]; 13(1):3-6. Disponible en: http://aulavirtual1.urp.edu.pe/ojs/index.php/RFMH/article/viewFile/160/119
10. Bich Chau TN, Anders KL, Lien LB, Hung NT, MinhHieu LT. Clinical and Virological Features of Dengue in Vietnamese Infants. PLoS Negl Trop Dis [Internet]. 2010 [citado 13 Abr 2018]; 4(4):e657. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/20405057
11. Picollo JF, Oliveira Burdmann EA. Dengue-associated acute kidney injury. Clin Kidney J [Internet]. 2015 [citado 13 Abr 2018]; 8(6):681–685. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655808/
12.Moraes GH, de Fátima Duarte E, Duarte EC. Determinants of mortality from severe dengue in Brazil: a population-based case-control study. Am J Trop Med Hyg [Internet]. 2013 [citado 13 Abr 2018]; 88(4):670-6. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/23400577
Published
2018-04-12
How to Cite
1.
Griñán Garrido Y, Plasencia Columbié Y, Díaz Ortiz A. Prediction of mortality in patients with severe dengue in the Intensive Care Unit. Rev Inf Cient [Internet]. 2018 Apr. 12 [cited 2025 Apr. 2];97(3):584-95. Available from: https://revinfcientifica.sld.cu/index.php/ric/article/view/1836
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