Clinical profile of patients with chronic urticaria at the Main Military Hospital, Guinea-Bissau
Keywords:
allergology, allergic disease, chronic urticaria, angioedemaAbstract
Introduction: chronic urticaria is a heterogeneous demarcated skin disease characterized by the development of wheals or hives.
Objective: determination of the clinical characteristics and the pharmacological treatment indicated in patients diagnosed with chronic urticaria.
Method: a quantitative, prospective, observational and descriptive study was conducted in a total of 48 patients (the universe) diagnosed with chronic urticaria, Main Military Hospital, Guinea-Bissau, 2018-2020. The following variables were used: age, sex, type of urticaria, time of evolution, comorbidity and treatment used in the first and last recorded consultation, as well as disease activity.
Results: the mean age was 38.52 years with a female predominance. The mean time of evolution of the disease was 4.67 years and 70.83 % did not present angioedema. Chronic spontaneous urticaria was the predominant type. cyproheptadine was the treatment most indicated to be used at baseline and at the end of treatment follow-up its use increased. montelukast was the other drug that increased its use at the end of follow-up. With the treatment used disease activity was reduced up to rates recognized as controlled chronic spontaneous urticaria.
Conclusions: chronic urticaria in Guinea-Bissau has prevalence and clinical manifestations in line with those reported worldwide, with treatment regimens susceptible to modifications depending on the early use of recommended drugs such as cyclosporine or omalizumab.
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References
2. Zamitiz-Hernández J, Celio-Murillo R, Torres-Reyes MA, León-Aguilar R, Ramírez-González V. Prevalencia de urticaria crónica en una unidad médica. Rev Alerg Méx [Internet]. 2021 [citado 5 Ene 2022]; 68(3):174-179. DOI: https://doi.org/10.29262/ram.v68i3.867
3. Herrera-Sánchez DA, Álvarez-Chávez FE, O´Farrill-Romanillos PM. Actividad de la urticaria crónica espontánea en pacientes eutiroideos versus hipotiroideos. Rev Alerg Méx [Internet]. 2020 Jun [citado 5 Ene 2022]; 67(2):112-118. DOI: https://doi.org/10.29262/ram.v67i2.635
4. Sugrañes-Montalván A, Barreto-Suarez E, Quesada-Leyva L. Urticaria por frío en un adolescente. MEDISAN [Internet]. 2019 [citado 5 Ene 2022]; 23(3):[aproximadamente 8 p.]. Disponible en: http://www.medisan.sld.cu/index.php/san/article/view/2318
5. Dabija D, Tadi P. Chronic Urticaria. StatPearls [Internet] 2019 [citado 5 Ene 2022]. Disponible en: https://www.ncbi.nlm.nih.gov/books/NBK555910/
6. Aguilera-Insunza R, Correa H, Díaz C, Marinovic MA, Valenzuela F. Guía clínica chilena de urticaria crónica espontánea. Rev Méd Chile [Internet]. 2018 [citado 5 Ene 2022]; 146(11):1334-1342. DOI: http://dx.doi.org/10.4067/S0034-98872018001101334
7. Sánchez-Villalobos JY, Huerta-Romero J. Urticaria aguda en pediatría. Bol Clin Hosp Inf Edo Son [Internet]. 2019 [citado 5 Ene 2022]; 36(2):72-79. Disponible en: https://www.medigraphic.com/pdfs/bolclinhosinfson/bis-2019/bis192d.pdf
8. Cruz-Hernández A, Caballero-López CG, López-García AI, Rivero-Yeverino D, Arana-Muñoz O, Papaqui-Tapia JS, et al. Prevalencia de la urticaria crónica y su perfil clínico epidemiológico. Alerg Asma Inmunol Ped [Internet]. 2019 [citado 5 Ene 2022]; 28(2):47-50. Disponible en: https://www.medigraphic.com/pdfs/alergia/al-2019/al192c.pdf
9. Silvestre-Salvador JF, Serrano-Manzano M, Serra-Baldrich E, Palacios-Martinez D, Gomez-de la Fuentes E, Heras-Hito JA, et al. Recomendaciones para el manejo de la urticaria en Atención Primaria. Medicina de Familia. SEMERGEN [Internet]. 2020 [citado 5 Ene 2022]; 46(4):270-276. DOI: http://dx.doi.org/10.1016/j.semerg.2019.12.006
10.Alcántara Villar M, Armario Hita JC, Cimbollek S, Fernández Ballesteros MD, Galán Gutiérrez M, Hernández Montoya C, et al. Revisión de las últimas novedades en el manejo del paciente con urticaria crónica: Consenso multidisciplinar de la comunidad autónoma de Andalucía. Actas Dermo-Sifiliogr [Internet]. 2020 [citado 5 Ene 2022]; 111(3):222-228. DOI: http://dx.doi.org/doi.org/10.1016/j.ad.2019.04.009
11.Coronado B, Ochoa-García IV, Torres-Lozano C, Quintero-Ramos A, Ortega-Cisneros M. Frecuencia y caracterización clínica de la urticaria crónica en un hospital de tercer nivel. Rev Alerg Méx [Internet]. 2021 Jun [citado 5 Ene 2022]; 68(2):94-100. DOI: http://dx.doi.org/doi.org/10.29262/ram.v658i2.818
12.Sedó-Mejía G, Lotz-Esquivel S, Monge-Ortega OP, Pino-García C. Perfil clínico de los pacientes con urticaria crónica en un hospital de tercer nivel de atención del sistema de seguridad social de Costa Rica. Rev Alerg Mex [Internet]. 2021 [citado 5 Ene 2022]; 68(4):225-232. DOI: https://doi.org/10.29262/ram.v68i4.881
13.Coelho Dias GA, Cunha Coelho F, Filippo P, Lacerda Pedrazzi D, Nogueira Arraes AC, Perelló MI, et al. Clinical experience of a chronic urticaria university referral center. Eur Ann Aller Clin Immunol [Internet]. 2021 [citado 31 Ago 2022]; 52(3):112-120. DOI: http://dx.doi.org/10.23822/EurAnnACI.1764-1489.103
14.Gómez RM, Jares E, Borges MS, Baiardini I, Walter-Canonica G, Passalacqua G, et al. Latin American chronic urticaria registry (CUR) contribution to the understanding and knowledge of the disease in the region. World Allergy Organ J [Internet]. 2019 [citado 31 Ago 2022]; 12(6):100042. DOI: https://doi.org/10.1016/j.waojou.2019.100042
15.Maurer M, Houghton K, Costa C, Dabove F, Ensina LF, Giménez-Arnau A, et al. Differences in chronic spontaneous urticaria between Europe and Central/South America: results of the multi-center real world AWARE study. World Allergy Organ J [Internet]. 2018 [citado 5 Ene 2022]; 11(1):32. Disponible en: https://pubmed.ncbi.nlm.nih.gov/30464782/
16.Sussman G, Abuzakouk M, Bérard F, Canonica W, Oude-Elberink HO, Giménez-Arnau A, et al. Angioedema in chronic spontaneous urticaria is underdiagnosed and has a substantial impact: analyses from ASSURE-CSU. Allergy [Internet]. 2018 [citado 5 Ene 2022]; 73(8):1724-1734. DOI: https://doi.org/10.1111/all.13430
17.Marín-Cabañas I, Berbegal-de Gracia L, de León-Marrero F, Hispán P, Silvestre JF. Management of chronic spontaneous urticariain routine clinical practice following the EAACI/GA(2)LEN/EDF/WAO guidelines. Actas Dermosifiliogr [Internet]. 2017 [citado 5 Ene 2022]; 108(4):346-353. DOI: https://doi.org/10.1016/j.ad.2016.12.012
18.Salman A, Demir G, Bekiroglu N. The impact of omalizumab on quality of life and its predictors in patients with chronic spontaneous urticaria: Real-life data. Dermatol Ther [Internet]. 2019 [citado 5 Ene 2022]; 32(4):e12975. DOI: https://doi.org/10.1111/dth.12975