Vitamin C and its action in cancer cells
Keywords:
vitamin C, oxidation, DNA, apoptotic cells, cancer cellsAbstract
Introduction: vitamin C is a water–soluble substance that has been in debate since a long time ago due to its wide demonstrated use. In some cases, its usage have ranged from prophylaxis and shortening the duration of colds, to studies of its action in diseases, such as cancer; Its mechanisms of action have been evaluated in the form of monotherapy or in combination with the chemotherapy to demonstrate or rule out its usefulness in cancer.
Objective: to demonstrate whether the effects of vitamin C were effective and whether its use, alone or in combination with chemotherapy, is useful.
Method: a documentary descriptive research was carried out, supported with scientific articles (period 2016 to 2021) which analyze in detail the results of the use of vitamin C and its possible effect on different types of cancer.
Results: the information found was organized according to plasma concentrations of vitamin C, its action on cancer cells, evaluated doses of vitamin C, mechanisms of action in relation to cancer cells, redox imbalance, specific effect on cancers, vitamin C and breast cancer.
Conclusions: the review shows that the use of vitamin C has a beneficial effect on hematopoietic cancers, such as leukemia, melanoma, breast cancer or certain types of colorectal cancer, and also reduces the adverse effects produced by chemotherapeutic drugs.
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References
2. Ang A, Pullar JM, Currie MJ, Vissers MCM. Vitamin C and immune cell function in inflammation and cancer. Biochem Soc Trans [Internet]. 2018 [citado 4 Abr 2022]; 46(5):1147-1159. DOI: https://doi.org/10.1042/BST20180169
3. Camarena V, Wang G. The epigenetic role of vitamin C in health and disease. Cell Mol Life Sci [Internet]. 2016 [citado 4 Abr 2022]; 73(8):1645-1658. Disponible en: https://link.springer.com/article/10.1007/s00018-016-2145-x
4. Lykkesfeldt J, Tveden-Nyborg P. The Pharmacokinetics of Vitamin C. Nutrients [Internet]. 2019 Oct [citado 4 Abr 2022]; 11(10):2412. DOI: https://doi.org/10.3390/nu11102412
5. Ngo B, Van Riper JM, Cantley LC, Yun J. Targeting cancer vulnerabilities with high-dose vitamin C. Nat Rev Cancer [Internet]. 2019 [citado 4 Abr 2022]; 19(5):271-282. Disponible en: https://www.nature.com/articles/s41568-019-0135-7
6. Padayatty SJ, Levine M. Vitamin C: the known and the unknown and Goldilocks. Oral Dis [Internet]. 2016 [citado 4 Abr 2022]; 22(6):463-493. DOI: https://doi.org/10.1111/odi.12446
7. Castillo-Velarde E. Vitamin C in health and disease. Rev Fac Med Hum [Internet]. 2019 Oct [citado 20 Mar 2022]; 19(4):95-100. DOI: http://dx.doi.org/10.25176/RFMH.v19i4.2351
8. Villagrán M, Muñoz M, Díaz F, Troncoso C, Celis-Morales C, Mardones L. Vitamin C in health and disease: a current perspective. Rev Chil Nutr [Internet]. 2019 Dec [citado 20 Mar 2022]; 46(6):800-808. DOI: http://dx.doi.org/10.4067/S0717-75182019000600800
9. Kaźmierczak-Barańska J, Boguszewska K, Adamus-Grabicka A, Karwowski BT. Two Faces of Vitamin C-Antioxidative and Pro-Oxidative Agent. Nutrients [Internet]. 2020 May [citado 4 Abr 2022]; 12(5):1501. DOI: https://doi.org/10.3390/nu12051501
10.Pawlowska E, Szczepanska J, Blasiak J. Pro- and Antioxidant Effects of Vitamin C in Cancer in correspondence to Its Dietary and Pharmacological Concentrations. Oxid Med Cell Longev [Internet]. 2019 Dec [citado 4 Abr 2022]; 2019:7286737. DOI: https://doi.org/10.1155/2019/7286737
11.Cimmino L, Neel BG, Aifantis I. Vitamin C in Stem Cell Reprogramming and Cancer. Trends Cell Biol [Internet]. 2018 [citado 4 Abr 2022]; 28(9):698-708. DOI: https://doi.org/10.1016/j.tcb.2018.04.001
12.Park S, Ahn S, Shin Y, Yang Y, Yeom CH. Vitamin C in Cancer: A Metabolomics Perspective. Front Physiol [Internet]. 2018 Jun [citado 4 Abr 2022]; 9:762. DOI: https://doi.org/10.3389/fphys.2018.00762
13.Shenoy N, Creagan E, Witzig T, Levine M. Ascorbic Acid in Cancer Treatment: Let the Phoenix Fly. Cancer Cell [Internet]. 2018 [citado 4 Abr 2022]; 34(5):700-706. DOI: https://doi.org/10.1016/j.ccell.2018.07.014
14.Fiorillo M, Tóth F, Sotgia F, Lisanti MP. Doxycycline, Azithromycin and Vitamin C (DAV): A potent combination therapy for targeting mitochondria and eradicating cancer stem cells (CSCs). Aging (Albany NY) [Internet]. 2019 [citado 4 Abr 2022]; 11(8):2202-2216. DOI: https://doi.org/10.18632/aging.101905
15.Blaszczak W, Barczak W, Masternak J, Kopczyński P, Zhitkovich A, Rubiś B. Vitamin C as a Modulator of the Response to Cancer Therapy. Molecules [Internet]. 2019 Jan [citado 4 Abr 2022]; 24(3):453. DOI: https://doi.org/10.3390/molecules24030453
16.Gillberg L, Ørskov AD, Liu M, Harsløf LBS, Jones PA, Grønbæk K. Vitamin C - A new player in regulation of the cancer epigenome. Semin Cancer Biol [Internet]. 2018 [citado 4 Abr 2022]; 51:59-67. DOI: https://doi.org/10.1016/j.semcancer.2017.11.001
17.van Gorkom GNY, Lookermans EL, Van Elssen CHMJ, Bos GMJ. The Effect of Vitamin C (Ascorbic Acid) in the Treatment of Patients with Cancer: A Systematic Review. Nutrients [Internet]. 2019 Apr [citado 4 Abr 2022]; 11(5):977. DOI: https://doi.org/10.3390/nu11050977
18.Klimant E, Wright H, Rubin D, Seely D, Markman M. Intravenous vitamin C in the supportive care of cancer patients: a review and rational approach. Curr Oncol [Internet]. 2018 [citado 4 Abr 2022]; 25(2):139-148. DOI: https://doi.org/10.3747/co.25.3790
19.Fu J, Wu Z, Liu J, Wu T. Vitamin C: A stem cell promoter in cancer metastasis and immunotherapy. Biomed Pharmacother [Internet]. 2020 [citado 4 Abr 2022]; 131:110588. DOI: https://doi.org/10.1016/j.biopha.2020.110588
20.Sant DW, Mustafi S, Gustafson CB, Chen J, Slingerland JM, Wang G. Vitamin C promotes apoptosis in breast cancer cells by increasing TRAIL expression. Sci Rep [Internet]. 2018 Mar [citado 4 Abr 2022]; 8(1):5306. Disponible en: https://www.nature.com/articles/s41598-018-23714-7
21.Lee SJ, Jeong JH, Lee IH, et al. Effect of High-dose Vitamin C Combined With Anti-cancer Treatment on Breast Cancer Cells. Anticancer Res [Internet]. 2019 [citado 4 Abr 2022]; 39(2):751-758. DOI: https://doi.org/10.21873/anticanres.13172
